EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy
JG Paez, PA Janne, JC Lee, S Tracy, H Greulich… - Science, 2004 - science.org
… lung cancer samples from US patients who responded to gefitinib therapy and in a lung …
hypersensitive to growth inhibition by gefitinib, but not in gefitinib-insensitive tumors or cell …
hypersensitive to growth inhibition by gefitinib, but not in gefitinib-insensitive tumors or cell …
Gefitinib therapy for non-small cell lung cancer
A Birnbaum, N Ready - Current treatment options in oncology, 2005 - Springer
… helped to define the characteristics of patients most likely to respond to gefitinib therapy. …
has helped to define the characteristics of patients most likely to respond to gefitinib therapy. …
has helped to define the characteristics of patients most likely to respond to gefitinib therapy. …
Gefitinib Therapy for Advanced Non–Small-Cell Lung Cancer
CY Liu, S Seen - Annals of Pharmacotherapy, 2003 - journals.sagepub.com
… All published trials and abstracts citing gefitinib were … Gefitinib, with a unique mechanism
of action and favorable toxicity … Further research is required to evaluate the use of gefitinib in …
of action and favorable toxicity … Further research is required to evaluate the use of gefitinib in …
Overview of gefitinib in non-small cell lung cancer: an Asian perspective
H Jiang - Japanese journal of clinical oncology, 2009 - academic.oup.com
… However, unlike NSCLC patients who receive gefitinib first-line, outcome from gefitinib
therapy in patients who had previously received chemotherapy appears to be consistent across …
therapy in patients who had previously received chemotherapy appears to be consistent across …
A phase II trial of gefitinib as first-line therapy for advanced non-small cell lung cancer with epidermal growth factor receptor mutations
H Asahina, K Yamazaki, I Kinoshita, N Sukoh… - … journal of cancer, 2006 - nature.com
… Sixteen patients were enrolled and treated with gefitinib. Twelve … gefitinib is very active and
well tolerated as first-line therapy … In conclusion, gefitinib treatment as first-line therapy for …
well tolerated as first-line therapy … In conclusion, gefitinib treatment as first-line therapy for …
[HTML][HTML] MET increased gene copy number and primary resistance to gefitinib therapy in non-small-cell lung cancer patients
… In the ONCOBELL cohort, no patient had gene amplification and MET gene copy number
was not associated with outcome to gefitinib therapy. Among the surgically resected patients, …
was not associated with outcome to gefitinib therapy. Among the surgically resected patients, …
Second‐line treatments after first‐line gefitinib therapy in advanced nonsmall cell lung cancer
JY Wu, JY Shih, CH Yang, KY Chen… - … journal of cancer, 2010 - Wiley Online Library
… with NSCLC after failure of first-line gefitinib, we carried out a … -line antitumor treatment after
gefitinib therapy. Clinical data … first-line gefitinib and at least 1 subsequent line therapy were …
gefitinib therapy. Clinical data … first-line gefitinib and at least 1 subsequent line therapy were …
Gefitinib for non-small-cell lung cancer treatment
A D'Incecco, F Cappuzzo - Expert opinion on drug safety, 2011 - Taylor & Francis
… Areas covered: All published data on gefitinib in lung cancer were analyzed using PubMed.
… of gefitinib in patients with advanced NSCLC. Expert opinion: EGFR-TKIs including gefitinib …
… of gefitinib in patients with advanced NSCLC. Expert opinion: EGFR-TKIs including gefitinib …
… to EGFR-tyrosine kinase inhibitor retreatment in non-small cell lung cancer patients who benefited from prior effective gefitinib therapy: a retrospective analysis
S Watanabe, J Tanaka, T Ota, R Kondo, H Tanaka… - BMC cancer, 2011 - Springer
… , this patient obtained SD with an initial gefitinib therapy of 4.3 months, and therefore we
considered this patient to have benefited from the gefitinib treatment. Further clinical trials are …
considered this patient to have benefited from the gefitinib treatment. Further clinical trials are …
Gefitinib for the treatment of non-small-cell lung cancer
L Campbell, F Blackhall, N Thatcher - Expert opinion on …, 2010 - Taylor & Francis
… The INTEREST (IRESSA NSCLC trial evaluating response and survival against taxotere)
trial reported survival following gefitinib therapy was not inferior to docetaxel chemotherapy in …
trial reported survival following gefitinib therapy was not inferior to docetaxel chemotherapy in …
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