… genes were used as positive controls for the reactions. Since several β-lactamases are encoded
on gene cassettes, … , the aadA1 gene cassette is followed by another β-lactamase gene …

… the 5′-end of a class 1 integron structure harbouring five gene cassettes, including one
encoding the metallo-β-lactamase VIM-1. It is likely that the IS26 element identified downstream …

… gene cassette. Class 1 integrons were detected in 54 IRPA clinical isolates, whilst three
isolates contained class 2 integrons. Analysis of the gene cassettes … -β-lactamase (MBL) genes (…

… -2 cassette was unrelated to those of thebla IMP cassettes found in Japanese isolates, indicating
a different phylogeny for the gene cassettes … nature of the gene cassettes carried by the …

… aeruginosa RON-1 and RON-2 contain the samebla VIM-2 gene cassette and additional
gene cassettes containing multiple aminoglycosideN-acetyltransferase genes. Characterization …

… typical of class 1 integrons and, in addition to the blaIMP-2 gene cassette, aacA4 and
aadA1 gene cassettes expressing resistance to several aminoglycosides. IMP-2 shares 85% …

… Integron inserted genes encode for various antibiotic … distinct genes, conferring resistance
to aminoglycosides, β-lactams… Concerning β-lactamases, integron-borne gene cassettes have …

… -lactams … --lactamase gene (blaIMP) cassette of Serratia marcescens AK9373 is located in
the space between the integrase gene (intI3) and the aminoglycoside acetyltransferase gene […

… -1 and VIM-2 metallo-β-lactamases have been reported in various Gram-negative … genes
occur in mobile gene cassettes inserted in the variable regions of integrons.3 Gene cassettes …

… the close association of the aadB gene cassette with bla SHV genes in ESBL-producing
Klebsiella, and in the present study, we show that both resistance genes are located on a single …