Impact of extracellular folate levels on global gene expression

MS Jhaveri, C Wagner, JB Trepel - Molecular Pharmacology, 2001 - ASPET
… in folate-mediated gene expression, we decided to investigate the methylation status of
folate-regulated genes … We determined the frequency of CpG dinucleotides within the αhFR gene

Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells

P Novakovic, JM Stempak, KJ Sohn, YI Kim - Carcinogenesis, 2006 - academic.oup.com
… of change in gene expression in response to folate deficiency … of genes showing ∼2-fold
change on average and no genes … intratumor folate levels and interruption of intratumor folate

Folate, alcohol, and liver disease

V Medici, CH Halsted - Molecular nutrition & food research, 2013 - Wiley Online Library
… mechanisms of relevant gene expressions. We also review … serum folate levels, including
44% with serum folate levels in … no association of low serum folate levels with severity of liver …

Folate‐mediated one‐carbon metabolism and neural tube defects: Balancing genome synthesis and gene expression

AE Beaudin, PJ Stover - Birth Defects Research Part C: Embryo …, 2007 - Wiley Online Library
… Identification of the mechanism by which folate status affects neural tube closure will assist …
between folate status and NTDs, with an emphasis on linking genetic variation, folate nutriture…

Altered gene expression of folate enzymes in adjacent mucosa is associated with outcome of colorectal cancer patients

E Odin, Y Wettergren, S Nilsson, R Willén… - Clinical cancer …, 2003 - AACR
… The FdUMP binding assay was used for measuring the folate levels in the mucosa (n = 45).
It was not possible to analyze >45 tissue samples, because the method requires a minimum …

Folate-regulated changes in gene expression in the anterior neural tube of folate binding protein-1 (Folbp1)-deficient murine embryos

O Spiegelstein, RM Cabrera, D Bozinov… - Neurochemical …, 2004 - Springer
… The findings of Jhaveri and colleagues (35) suggested that folate levels regulate the expression
of specific genes by selective methylation and demethylation of their regulatory elements…

[HTML][HTML] Folate pathway gene expression differs in subtypes of acute lymphoblastic leukemia and influences methotrexate pharmacodynamics

L Kager, M Cheok, W Yang, G Zaza… - The Journal of …, 2005 - Am Soc Clin Investig
… Though it was not the primary objective of our study, we established distinct correlation
structures in gene expression patterns among the candidate folate pathway genes in ALL cells. …

Folate depletion changes gene expression of fatty acid metabolism, DNA synthesis, and circadian cycle in male mice

J Champier, F Claustrat, N Nazaret, MF Montange… - Nutrition Research, 2012 - Elsevier
folate depletion alters gene expression. To test this hypothesis, we investigated the effects of
folate deficiency on gene expression … on genes coding for proteins differentially expressed

Interactions between folate intake and genetic predictors of gene expression levels associated with colorectal cancer risk

CB Haas, YR Su, P Petersen, X Wang, SA Bien, Y Lin… - Scientific reports, 2022 - nature.com
… interactions between folate consumption and predicted gene expression on … gene expression
as a priori variant information for a set-based G × E approach. We harmonized total folate

[HTML][HTML] Molecular determinants of folate levels after leucovorin administration in colorectal cancer

S Sadahiro, T Suzuki, Y Maeda, A Tanaka… - Cancer chemotherapy …, 2010 - Springer
… and low ATP-binding cassette sub-family C, number 1 (ABCC1) gene expression in CRC
tissues were predictive factors for a high reduced folate level after LV administration. …