Global functional profiling of gene expression
… genes into functional profiles characterizing the impact of the condition studied. OE constructs
functional profiles (using Gene Ontology terms) for the following categories: biochemical …
functional profiles (using Gene Ontology terms) for the following categories: biochemical …
Gene expression elucidates functional impact of polygenic risk for schizophrenia
… resource of the genetics of gene expression in the brain. This … gene expression of genetic
variants previously implicated in risk; (ii) genes showing a significant difference in expression …
variants previously implicated in risk; (ii) genes showing a significant difference in expression …
Regulation of mTORC1 and its impact on gene expression at a glance
M Laplante, DM Sabatini - Journal of cell science, 2013 - journals.biologists.com
… Here, we review the impact of mTORC1 on gene expression by focusing on its impact on
the activity of transcription factors including STAT3, SREBPs, PPARγ, PPARα, HIF1α, YY1–…
the activity of transcription factors including STAT3, SREBPs, PPARγ, PPARα, HIF1α, YY1–…
Basic concepts of epigenetics: impact of environmental signals on gene expression
EA Mazzio, KFA Soliman - Epigenetics, 2012 - Taylor & Francis
… gene expression. Topics covered include the connection between DNA methylation,
methyl-CpG-binding proteins, transcriptional repression complexes, histone residues, histone …
methyl-CpG-binding proteins, transcriptional repression complexes, histone residues, histone …
The impact of chromosomal rearrangements on regulation of gene expression
L Harewood, P Fraser - Human molecular genetics, 2014 - academic.oup.com
… Both types of rearrangement have been shown to have impacts on gene expression
through a variety of different mechanisms, some of which are outlined in this review. …
through a variety of different mechanisms, some of which are outlined in this review. …
The impact of human copy number variation on gene expression
ER Gamazon, BE Stranger - Briefings in functional genomics, 2015 - academic.oup.com
… CNV and the transcriptome: disease susceptibility and genome function Gene expression …
thus, a comprehensive survey of the impact of CNVs on variation in gene regulation can have …
thus, a comprehensive survey of the impact of CNVs on variation in gene regulation can have …
Exploring functional relationships between components of the gene expression machinery
T Burckin, R Nagel, Y Mandel-Gutfreund… - Nature structural & …, 2005 - nature.com
… of gene expression is based on a combination of genetic and biochemical methods to assign
roles to specific factors in separate steps of the gene expression … and genetic interactions …
roles to specific factors in separate steps of the gene expression … and genetic interactions …
[HTML][HTML] The impact of rare variation on gene expression across tissues
… Overall, we demonstrate that rare variants contribute to large gene expression changes
across tissues and provide an integrative method for interpretation of rare variants in individual …
across tissues and provide an integrative method for interpretation of rare variants in individual …
Impact of microRNA regulation on variation in human gene expression
… , and here we consider the role of miRNAs in canalization of gene expression in humans. …
target sites on gene expression variation. Finally, we explore the impact of miRNA regulation …
target sites on gene expression variation. Finally, we explore the impact of miRNA regulation …
The impact of sex on gene expression across human tissues
M Oliva, M Muñoz-Aguirre, S Kim-Hellmuth, V Wucher… - Science, 2020 - science.org
… in gene expression levels (sex-biased gene expression) and cis sex‐biased expression …
By incorporating the results of these sex-aware analyses of GTEx data with gene features and …
By incorporating the results of these sex-aware analyses of GTEx data with gene features and …
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