Global functional profiling of gene expression

S Drǎghici, P Khatri, RP Martins, GC Ostermeier… - Genomics, 2003 - Elsevier
genes into functional profiles characterizing the impact of the condition studied. OE constructs
functional profiles (using Gene Ontology terms) for the following categories: biochemical …

Gene expression elucidates functional impact of polygenic risk for schizophrenia

M Fromer, P Roussos, SK Sieberts, JS Johnson… - Nature …, 2016 - nature.com
… resource of the genetics of gene expression in the brain. This … gene expression of genetic
variants previously implicated in risk; (ii) genes showing a significant difference in expression

Regulation of mTORC1 and its impact on gene expression at a glance

M Laplante, DM Sabatini - Journal of cell science, 2013 - journals.biologists.com
… Here, we review the impact of mTORC1 on gene expression by focusing on its impact on
the activity of transcription factors including STAT3, SREBPs, PPARγ, PPARα, HIF1α, YY1–…

Basic concepts of epigenetics: impact of environmental signals on gene expression

EA Mazzio, KFA Soliman - Epigenetics, 2012 - Taylor & Francis
gene expression. Topics covered include the connection between DNA methylation,
methyl-CpG-binding proteins, transcriptional repression complexes, histone residues, histone …

The impact of chromosomal rearrangements on regulation of gene expression

L Harewood, P Fraser - Human molecular genetics, 2014 - academic.oup.com
… Both types of rearrangement have been shown to have impacts on gene expression
through a variety of different mechanisms, some of which are outlined in this review. …

The impact of human copy number variation on gene expression

ER Gamazon, BE Stranger - Briefings in functional genomics, 2015 - academic.oup.com
… CNV and the transcriptome: disease susceptibility and genome function Gene expression
thus, a comprehensive survey of the impact of CNVs on variation in gene regulation can have …

Exploring functional relationships between components of the gene expression machinery

T Burckin, R Nagel, Y Mandel-Gutfreund… - Nature structural & …, 2005 - nature.com
… of gene expression is based on a combination of genetic and biochemical methods to assign
roles to specific factors in separate steps of the gene expression … and genetic interactions …

[HTML][HTML] The impact of rare variation on gene expression across tissues

X Li, Y Kim, EK Tsang, JR Davis, FN Damani, C Chiang… - Nature, 2017 - nature.com
… Overall, we demonstrate that rare variants contribute to large gene expression changes
across tissues and provide an integrative method for interpretation of rare variants in individual …

Impact of microRNA regulation on variation in human gene expression

J Lu, AG Clark - Genome research, 2012 - genome.cshlp.org
… , and here we consider the role of miRNAs in canalization of gene expression in humans. …
target sites on gene expression variation. Finally, we explore the impact of miRNA regulation …

The impact of sex on gene expression across human tissues

M Oliva, M Muñoz-Aguirre, S Kim-Hellmuth, V Wucher… - Science, 2020 - science.org
… in gene expression levels (sex-biased gene expression) and cis sex‐biased expression
By incorporating the results of these sex-aware analyses of GTEx data with gene features and …