NF-κB in immunobiology

MS Hayden, S Ghosh - Cell research, 2011 - nature.com
NF-κB dimers can bind to a variety of related target DNA sequences called κB sites to modulate
gene expression… co-activator recruitment and target gene expression. As they lack TADs, …

[PDF][PDF] Oxidative stress and gene expression: the AP-1 and NF-kappaB connections

M Karin, T Takahashi, P Kapahi, M Delhase… - BIOFACTORS …, 2001 - academia.edu
… In conclusion, we find little role for oxidants in the positive regulation of NF-κB, but through
inhibition of NF-κB which protects cells from apoptosis, oxidants can sensitize cells to …

The role of NFκB in hypoxia‐induced gene expression

CT Taylor, EP Cummins - Annals of the New York Academy of …, 2009 - Wiley Online Library
… sensitivity to both HIF and NF-κB−dependent gene expression. Furthermore, there is an …
between NF-κB and HIF. Investigations into mechanisms of hypoxic activation of HIF and NF-κB

Activation of interleukin-6 gene expression through the NF-κB transcription factor

TA Libermann, D Baltimore - Molecular and cellular biology, 1990 - Taylor & Francis
… the possibility that activation of NF-KB represents an important step in the regulation of IL-6
gene expression. We show here by electrophoretic mobility shift assays that NF-KB binds …

Oscillations in NF-κB signaling control the dynamics of gene expression

DE Nelson, AEC Ihekwaba, M Elliott, JR Johnson… - Science, 2004 - science.org
NF-κB localization coupled to cycles of RelA and IκBα phosphorylation maintain NF-κB–dependent
gene expression… as 30 min have been shown to maintain NF-κB activity in T cells (25)…

Evidence for involvement of NF-κB in the transcriptional control of COX-2 gene expression by IL-1β

R Newton, LME Kuitert, M Bergmann, IM Adcock… - Biochemical and …, 1997 - Elsevier
… /p65 NF-κB heterodimers in an IL-1β-dependent manner and that the upstream element has
the greater affinity. Finally, we demonstrate that the two NF-κB … that this may involve NF-κB. …

A TNF-induced gene expression program under oscillatory NF-κB control

B Tian, DE Nowak, AR Brasier - BMC genomics, 2005 - Springer
… analyzed the kinetics of NF-κB-dependent gene expression. Our findings suggest that NF-κB
controls distinct groups of target genes whose pattern of expression appear to be an …

Role of iron in NF-kappa B activation and cytokine gene expression by rat hepatic macrophages

M Lin, RA Rippe, O Niemela… - American Journal …, 1997 - journals.physiology.org
… iron and NF-KB in Kupffer cell cytokine gene expression, we utilized cultured Kupffer cells.
Because endotoxemia is common in cholestatic liver injury and LPS is a potent agonist for NF-…

NF-κB and IκBα are found in the mitochondria: evidence for regulation of mitochondrial gene expression by NF-κB

PC Cogswell, DF Kashatus, JA Keifer… - Journal of Biological …, 2003 - ASBMB
… nuclear gene or genes regulated by NF-κB encode … NF-κB may regulate mitochondrial gene
expression and whether other transcripts may be positively or negatively controlled by NF-κB

A nucleosomal function for IκB kinase-α in NF-κB-dependent gene expression

V Anest, JL Hanson, PC Cogswell, KA Steinbrecher… - Nature, 2003 - nature.com
… previously associated with positive gene expression. Furthermore, … regulator of NF-κB-dependent
gene expression through … role of the IKK complex in NF-κB-regulated gene expression. …