Analysis of a large prostate cancer family identifies novel and recurrent gene fusion events providing evidence for inherited predisposition

K Raspin, DE O'Malley, JR Marthick, S Donovan… - … Prostate, 2022 - Wiley Online Library
… and limited scope of gene fusion studies in familial PrCa, the … and diversity of gene fusions
in multiple prostate tumours from … fusions in PcTas9 was 64.3% and involved five distinct gene

Recurrent gene fusions in prostate cancer

C Kumar-Sinha, SA Tomlins, AM Chinnaiyan - Nature Reviews Cancer, 2008 - nature.com
… expression of ERG–ETV1 may be a key molecular event in a subset of prostate cancers. …
expression of other Ets family genes and discovered more gene fusions, such as TMPRSS2– …

ETS fusion genes in prostate cancer

DG Tandefelt, J Boormans, K Hermans… - … -related cancer, 2014 - erc.bioscientifica.com
… the family of ETS transcription factors. At lower frequency, other members of this gene
family … Although all other ETS gene fusion events are between genes that map on different …

ETS gene fusions in prostate cancer

JP Clark, CS Cooper - Nature Reviews Urology, 2009 - nature.com
gene family members are common events in human prostateevent in prostate cancer, the
expression of ETS gene fusionsgene expression has been reported in metastatic prostate

Common gene rearrangements in prostate cancer

MA Rubin, CA Maher, AM Chinnaiyan - Journal of Clinical Oncology, 2011 - ascopubs.org
… Since the initial discovery of ETS fusions in prostate cancer, several recent studies have
identified fusion events involving additional ETS family members (ie, ELK4, 9,10 ) novel 5′ (ie, …

Re-evaluate fusion genes in prostate cancer

T Wei, J Lu, T Ma, H Huang, JP Kocher… - Cancer …, 2021 - journals.sagepub.com
… The top candidates include ETS gene family members: ERG (26 … fusion genes using TCGA
prostate cancer cohort Thousands of fusion events have been reported in prostate cancer. …

Next-generation sequencing reveals novel rare fusion events with functional implication in prostate cancer

I Teles Alves, T Hartjes, E McClellan, S Hiltemann… - Oncogene, 2015 - nature.com
… MPP5 is a member of the membrane-associated guanylate kinase family and contributes
to the establishment of cell polarity in mammals, which is crucial for tissue organization and …

Recurrent gene fusions in prostate cancer: their clinical implications and uses

D Hessels, JA Schalken - Current urology reports, 2013 - Springer
Gene fusions involving other ETS family members or members of the RAS-RAF signalling …
, and currently gene fusions have to be considered as stochastic events for which DNA double-…

Prostate cancer subtyping and differential methylation analysis based on the ETS family of transcription factors fusion genes

W Niu, G Li, T Zhang, L Ma - Scientific Reports, 2024 - nature.com
… In this study, we proposed considering the ETS family gene fusions in … fusion events of
PCa fusion genes were mainly concentrated on chromosomes 1, 4, and 21, with fusion events

[HTML][HTML] Overview of research on fusion genes in prostate cancer

C Song, H Chen - Translational Cancer Research, 2020 - ncbi.nlm.nih.gov
… In addition to the ERG and ETV1 genes, other members of the ETS family were also … The
high-frequency of the USP9Y-TTTY15 fusion suggested that it might be a physiologic event and …