… the location of a gene relative to its interphase chromosome territory affects its regulation or
its … Hox gene clusters have provided important insights into the dynamic repositioning of a …

… genes are arranged in thehuman interphase nucleus among the 46 chromosome territories
… All of this regulation takes place within theconfines of the cell nucleus having an average …

… study of gene regulation.1-17 Rather than studying individual genes and their regulation, the
… now on understanding the regulation and coordination of up to 1000s of genes at any given …

… The dissociation of gene localization relative to their CTs and gene regulation was
shown for the murine Hoxd locus during differentiation and development: Although both …

Despite decades of study of chromosome territories (CT) in the interphase nucleus of mammalian
cells, our understanding of the global shape and 3-D organization of the individual CT …

… may be intently related to genomic function, global regulation of gene expression, and even
… of the chromosome territories phenomenon and briefly describe how genes relocation in …

… 2 , that affect gene regulation at the chromatin level are not … a higher level of the regulation
of gene expression and other … cell nucleus based on chromosome territories (CTs) and an …

… , chromosome territories suggests that chromosome territories … and how genes are leaving
the chromosome territories and … active genes are located outside chromosome territories 12 . …

… a spatial organization within territories that is conserved … chromosome territories in both
species. However, we do not detect genes necessarily at the periphery of chromosome territories …

… where each chromosome is confined to a discrete region, referred to as a chromosome
territory. This spatial organization is emerging as a crucial aspect of gene regulation and genome …