VEGF gene therapy: therapeutic angiogenesis in the clinic and beyond

M Giacca, S Zacchigna - Gene therapy, 2012 - nature.com
… To improve efficacy of therapeutic angiogenesis based on the VEGF-A gene for patients … to
angiogenic factor cDNA delivery, is to activate expression of the endogenous gene using zinc-…

Gene therapy progress and prospects: therapeutic angiogenesis for limb and myocardial ischemia

TA Khan, FW Sellke, RJ Laham - Gene Therapy, 2003 - nature.com
… , gene therapy has been established as a potential method to … therapeutic angiogenesis in
patients with ischemic cardiovascular disease. Therapeutic angiogenesis using gene therapy

Growth factor-induced therapeutic angiogenesis and arteriogenesis in the heart–gene therapy

JE Markkanen, TT Rissanen, A Kivelä… - Cardiovascular …, 2005 - academic.oup.com
… targets of gene therapy. … gene therapy approaches have been used so far, and more
thorough preclinical studies are needed in order to establish safe, efficient pro-angiogenic therapy

VEGF gene therapy: stimulating angiogenesis or angioma-genesis?

P Carmeliet - Nature medicine, 2000 - nature.com
gene therapy is useful for therapeuticangiogenesis’ without risking ‘angioma-genesis’. …
Notwithstanding these questions, the therapeutic potential for VEGF in induction of angiogenesis/…

Arterial gene therapy for therapeutic angiogenesis in patients with peripheral artery disease

JM Isner, K Walsh, J Symes, A Pieczek, S Takeshita… - Circulation, 1995 - Am Heart Assoc
… of vascular disorders, including therapeutic angiogenesis. … that transferring the gene encoding
that protein (ie, gene therapy) is … 165 arterial gene therapy for therapeutic angiogenesis. …

Angiogenesis gene therapy to rescue ischaemic tissues: achievements and future directions

C Emanueli, P Madeddu - British journal of pharmacology, 2001 - Wiley Online Library
… This review will debate the relevance of therapeutic angiogenesis for promotion of tissue …
systems for angiogenesis gene transfer, (c) achievements of therapeutic angiogenesis in …

Gene therapy for myocardial angiogenesis

DW Losordo, PR Vale, JM Isner - American heart journal, 1999 - Elsevier
… transfer may be used to successfully accomplish therapeutic angiogenesis. More recently, …
gene transfer may be used to safely and successfully accomplish therapeutic angiogenesis in …

Gene therapy for therapeutic angiogenesis in critically ischaemic lower limb–on the way to the clinic

TT Rissanen, I Vajanto… - European journal of …, 2001 - Wiley Online Library
… We conclude that angiogenic gene therapy may provide a novel treatment option for patients
with peripheral and myocardial ischaemia not amenable to conventional revascularization. …

Controlling the vasculature: angiogenesis, anti-angiogenesis and vascular targeting of gene therapy

TPD Fan, R Jagger, R Bicknell - Trends in pharmacological sciences, 1995 - cell.com
Gene therapy (see below) could also be used to target therapeutic stimulation of
angiogenesis. For example, direct gene transfer of aFGF into porcine arteries has been shown to …

Therapeutic angiogenesis for peripheral artery disease: gene therapy

Nikol - Vasa, 2007 - econtent.hogrefe.com
… II clinical gene therapy for peripheral artery disease trials for therapeutic angiogenesis are
… A number of other phase II clinical gene therapy trials are under way using the genes of new …