… Neural tube defects (NTDs) are common birth defects (~1 in 1000 … origins, including
environmental and genetic factors. A low level … that variants in additional folate/B12 pathway …

… Other genetic variants reported in the present review are less likely to be associated with
NTD risk. More studies in sufficiently large populations are required to determine possible …

… ), suggesting that gene-dosage can affect neural tube closure. … mutation screening of candidate
genes has been carried out … of sequence variants in or near candidate genes. Most work …

… Although genetic variants have been identified in folate-related genes that increase the risk
… genetic variation identified to date in these genes does not account for the overall genetic …

Background Neural Tube Defects (NTDs) are among the most prevalent and most severe
congenital malformations worldwide. Polymorphisms in key genes involving the folate pathway …

… gene VANGL1 associated with NTDs. The aim of the present study was to define the role
of VANGL1 genetic variants … We identified five novel missense variants in VANGL1, p.Ser83Leu…

… tube defects (NTDs) represent a common group of severe congenital malformations that
result from failure of neural tube … role of folate pathway gene variants and their interaction with …

… it is possible that particular combinations of genetic variants may underlie NTD susceptibility.
… By virtue of this, it is likely that critical combinations of variant alleles will be responsible for …

… While we could not demonstrate a significant contribution of FZD3 gene, we identified five
rare FZD6 variants that were absent in all controls and predicted to have a functional effect by …

… Neural tube defects are severe congenital malformations affecting around one in every …
Genetic predisposition accounts for most of the risk of neural tube defects, and genes that …