Clinical significance of genetic aberrations in secondary acute myeloid leukemia

JD Milosevic, A Puda, L Malcovati… - American journal of …, 2012 - Wiley Online Library
genetic lesions in sAML and dnAML, and analyze their prognostic significance in order to
define which genetic aberrations … co-occurrence of genetic aberrations and their association …

Genetic and chromosomal aberrations and their clinical significance in renal neoplasms

NY Yap, R Rajandram, KL Ng, J Pailoor… - BioMed research …, 2015 - Wiley Online Library
… Knowledge of these genetic changes in hereditary and sporadic … In this review, the genetic
aberrations characteristic to each … The potential applications of these genetic aberrations and …

[HTML][HTML] Molecular basis and clinical significance of genetic aberrations in B-cell precursor acute lymphoblastic leukemia

F Ghazavi, T Lammens, N Van Roy, B Poppe… - Experimental …, 2015 - Elsevier
… ALL) arises from recurrent genetic insults that block precursor B… Recent developments in
genomewide genetic analysis have … In this review, we discuss the established and novel genetic

The biology and clinical significance of acquired genomic copy number aberrations and recurrent gene mutations in chronic lymphocytic leukemia

SN Malek - Oncogene, 2013 - nature.com
… and clinical significance of individual genomic lesions and recurrent gene mutations. Finally,
… the biological and clinical effects of recurrent genomic aberrations or gene mutations on …

Genetic aberrations in paediatric acute leukaemias and implications for management of patients

T Szczepański, CJ Harrison, JJM van Dongen - The lancet oncology, 2010 - thelancet.com
… we summarise the most common genetic aberrations for the three … Several genetic aberrations
are independent prognostic … prognostic significance is dependent on which partner genes

Applications of fluorescence in situ hybridization (FISH) in detecting genetic aberrations of medical significance

R Bishop - Bioscience Horizons, 2010 - academic.oup.com
… as gene mapping or the identification of novel oncogenes or genetic aberrations that … or
absence of a particular genetic aberration when viewed under fluorescence microscopy. The …

Induced chromosomal aberrations: biological and clinical significance

AD Bloom - The Journal of Pediatrics, 1972 - Elsevier
… these are not purely genetic phenomena, genetic factors play a significant role in each of
them… Hiroshima and Nagasaki survivors suggests not that genetic effects did not take place, but …

Genetic aberration analysis of mitochondrial respiratory complex I implications in the development of neurological disorders and their clinical significance

GM Dar, E Ahmad, A Ali, B Mahajan, GM Ashraf… - Ageing research …, 2023 - Elsevier
… I subunit genes mutated are frequently of nuclear origin; however, most of the mtDNA gene
encoding subunits are also primarily involved. In this review, we have discussed the genetic

Prognostic significance of molecular genetic aberrations on chromosome segment 11p15. 5 in non–small-cell lung cancer

G Bepler, A Gautam, LM McIntyre, AF Beck… - Journal of clinical …, 2002 - ascopubs.org
… allele loss often heralds the discovery of genes with key functions in tumor … gene (RRM1)
within this region has been identified. We investigated the frequency and clinical significance of …

Prognostic implications of genetic aberrations in acute myelogenous leukemia with normal cytogenetics

H Ghanem, N Tank, IA Tabbara - American journal of …, 2012 - Wiley Online Library
… more importantly of predictive clinical significance have been discovered. Multiple studies
have shown that CN-AML patients usually exhibit two or more genetic aberrations. Despite the …