… that genetic activation of glucokinase specifically in α-cells … of GCK activation on GSGS,
we generated an α-cell specific … to as “α-mutGCK”). In this model, the wild-type glucokinase …

… , we compared INS-1E cells exposed to IL-1β or TNF-α with 208F cells … gene; and 7) ERK1/2
activation by IL-1β in INS-1E cells, but not by TNF-α in INS-1E cells or by IL-1β in 208F cells. …

… and the link between chronically elevated glucose or fatty acids and β-cell decompensation
… -activated receptor (PPAR) gene expression in the β-cell. Islets or INS(832/13) β-cells …

… To this end, we have studied α-cell activity at the level of the perfused pancreas, intact
and … -activated cell sorter (FACS)-isolated adherent α-cells. The suppressive action of β-cell …

… PPARα gene expression in INS-1E cells is independent of β-cell excitation and insulin secretion
but requires activation of … of the AMP-activated protein kinase (AMPK). Pharmacological …

… two in vivo genetic approaches: cell ablation combined with cell … gene inhibition and
activation of β-cell-specific genes 36 , or Pax4, which regulates the balance between α- and β-cells …

… cells, we assessed the expression of selected genes involved in endothelial cell activation in
islets … We also examined islet endotheliuml/oxidative stress (OS)/inflammation-related gene …

… Our results suggested ATF3 to be a stress-inducible, proapoptotic gene in β cells. … (glucagon-positive
α cells at the periphery of the islets and insulin-positive β cells at the core). These …

… cells, ER stress was intrinsically induced by mutant insulin expression. The WFS1 gene …
human WFS1 promoter was activated by chemically induced ER stress in MIN6 cells, and that …

… and activated stellate cells; and four types of immune cells. … - cells, we detected heterogeneity
in the regulation of genes … bulk gene expression samples using the single-cell data to …