Genetic risk scores identify genetic aetiology of inflammatory bowel disease phenotypes

MD Voskuil, LM Spekhorst… - Journal of Crohn's …, 2021 - academic.oup.com
… We used genetic risk scores [GRS] to disentangle the genetic … increased genetic risk of CD
is associated with fibrostenotic CD. We also validate the putatively shared genetic aetiology of …

High genetic risk score is associated with early disease onset, damage accrual and decreased survival in systemic lupus erythematosus

S Reid, A Alexsson, M Frodlund, D Morris… - Annals of the …, 2020 - ard.bmj.com
… A genetic risk score (GRS) was assigned to each individual based on 57 SLE risk loci. …
Genetic risk scores (GRSs) have been applied in several fields of medicine, and studies have …

The use of polygenic risk scores to identify phenotypes associated with genetic risk of bipolar disorder and depression: A systematic review

S Mistry, JR Harrison, DJ Smith, V Escott-Price… - Journal of affective …, 2018 - Elsevier
genetic risk for MDD and BD is manifest in the adult population as a broad range of
psychopathologies. As the literature on genetic risk scores for … how or whether genetic risk

PRSice: polygenic risk score software

J Euesden, CM Lewis, PF O'reilly - Bioinformatics, 2015 - academic.oup.com
… Here we illustrate the use of PRSice to test for shared genetic aetiology between traits. We
first investigate the genetic relationship between schizophrenia (SCZ) and major depressive …

Genetic aetiology of self-harm ideation and behaviour

AI Campos, KJH Verweij, DJ Statham, PAF Madden… - Scientific reports, 2020 - nature.com
… Finally, we test whether polygenic risk scores (PRS) for self-harm ideation and self-harm
behaviour predict suicide attempt, suicide thoughts and non-suicidal self-harm (NSSH) in an …

Clinical and research uses of genetic risk scores in type 1 diabetes

SA Sharp, MN Weedon, WA Hagopian… - … opinion in genetics & …, 2018 - Elsevier
… This review discusses the clinical and research utility of genetic risk scores in T1D particularly
… uses of genetic risk scores in big data and the limitations of using a genetic risk score. The …

Genomic risk score offers predictive performance comparable to clinical risk factors for ischaemic stroke

G Abraham, R Malik, E Yonova-Doing, A Salim… - Nature …, 2019 - nature.com
… In this study, we developed a genomic risk score for IS based on GWAS summary statistics
… to previously published genetic scores and measures of established non-genetic risk factors, …

Shared genetic aetiology between cognitive ability and cardiovascular disease risk factors: Generation Scotland's Scottish family health study

M Luciano, GD Batty, M McGilchrist, P Linksted… - Intelligence, 2010 - Elsevier
… Here we examine whether general cognitive ability and CVD risk factors share genetic
and/or environmental aetiology. In this large, pedigree-based cross-sectional study of Scottish …

Genetic risk prediction in complex disease

L Jostins, JC Barrett - Human molecular genetics, 2011 - academic.oup.com
… of each individual as high or low risk, or a quantitative risk score that represents the degree
of risk for each individual. Optimally, such a risk score is equal to the posterior probability of …

Risk prediction of prevalent diabetes in a Swiss population using a weighted genetic score—the CoLaus Study

X Lin, K Song, N Lim, X Yuan, T Johnson… - Diabetologia, 2009 - Springer
genes [18]. We next compared the predictive value of this weighted genetic score with the
unweighted score. … power of the weighted additive genetic score over the clinical predictors of …