Genetic risk scores identify genetic aetiology of inflammatory bowel disease phenotypes
MD Voskuil, LM Spekhorst… - Journal of Crohn's …, 2021 - academic.oup.com
… We used genetic risk scores [GRS] to disentangle the genetic … increased genetic risk of CD
is associated with fibrostenotic CD. We also validate the putatively shared genetic aetiology of …
is associated with fibrostenotic CD. We also validate the putatively shared genetic aetiology of …
High genetic risk score is associated with early disease onset, damage accrual and decreased survival in systemic lupus erythematosus
S Reid, A Alexsson, M Frodlund, D Morris… - Annals of the …, 2020 - ard.bmj.com
… A genetic risk score (GRS) was assigned to each individual based on 57 SLE risk loci. …
Genetic risk scores (GRSs) have been applied in several fields of medicine, and studies have …
Genetic risk scores (GRSs) have been applied in several fields of medicine, and studies have …
The use of polygenic risk scores to identify phenotypes associated with genetic risk of bipolar disorder and depression: A systematic review
… genetic risk for MDD and BD is manifest in the adult population as a broad range of
psychopathologies. As the literature on genetic risk scores for … how or whether genetic risk …
psychopathologies. As the literature on genetic risk scores for … how or whether genetic risk …
PRSice: polygenic risk score software
… Here we illustrate the use of PRSice to test for shared genetic aetiology between traits. We
first investigate the genetic relationship between schizophrenia (SCZ) and major depressive …
first investigate the genetic relationship between schizophrenia (SCZ) and major depressive …
Genetic aetiology of self-harm ideation and behaviour
… Finally, we test whether polygenic risk scores (PRS) for self-harm ideation and self-harm
behaviour predict suicide attempt, suicide thoughts and non-suicidal self-harm (NSSH) in an …
behaviour predict suicide attempt, suicide thoughts and non-suicidal self-harm (NSSH) in an …
Clinical and research uses of genetic risk scores in type 1 diabetes
… This review discusses the clinical and research utility of genetic risk scores in T1D particularly
… uses of genetic risk scores in big data and the limitations of using a genetic risk score. The …
… uses of genetic risk scores in big data and the limitations of using a genetic risk score. The …
Genomic risk score offers predictive performance comparable to clinical risk factors for ischaemic stroke
… In this study, we developed a genomic risk score for IS based on GWAS summary statistics
… to previously published genetic scores and measures of established non-genetic risk factors, …
… to previously published genetic scores and measures of established non-genetic risk factors, …
Shared genetic aetiology between cognitive ability and cardiovascular disease risk factors: Generation Scotland's Scottish family health study
… Here we examine whether general cognitive ability and CVD risk factors share genetic
and/or environmental aetiology. In this large, pedigree-based cross-sectional study of Scottish …
and/or environmental aetiology. In this large, pedigree-based cross-sectional study of Scottish …
Genetic risk prediction in complex disease
L Jostins, JC Barrett - Human molecular genetics, 2011 - academic.oup.com
… of each individual as high or low risk, or a quantitative risk score that represents the degree
of risk for each individual. Optimally, such a risk score is equal to the posterior probability of …
of risk for each individual. Optimally, such a risk score is equal to the posterior probability of …
Risk prediction of prevalent diabetes in a Swiss population using a weighted genetic score—the CoLaus Study
X Lin, K Song, N Lim, X Yuan, T Johnson… - Diabetologia, 2009 - Springer
… genes [18]. We next compared the predictive value of this weighted genetic score with the
unweighted score. … power of the weighted additive genetic score over the clinical predictors of …
unweighted score. … power of the weighted additive genetic score over the clinical predictors of …
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