The genetic changes of Wilms tumour
TD Treger, T Chowdhury, K Pritchard-Jones… - Nature Reviews …, 2019 - nature.com
… of the genetic landscape that underpins Wilms tumour. We begin with the epidemiology,
focusing on the narrow developmental window of Wilms tumour and the genetic risk factors that …
focusing on the narrow developmental window of Wilms tumour and the genetic risk factors that …
[HTML][HTML] Wilms tumour
F Spreafico, CV Fernandez, J Brok, K Nakata… - Nature Reviews …, 2021 - nature.com
… renal tumours: ~90% being Wilms tumours (WTs) and ~10% other primary renal tumours. In
… hyperplastic nephrogenic rests, with typical genetic changes. Nephrogenic rests are found in …
… hyperplastic nephrogenic rests, with typical genetic changes. Nephrogenic rests are found in …
Wilms' tumour: reconciling genetics and biology
V Van Heyningen, ND Hastie - Trends in Genetics, 1992 - Elsevier
… genetics are turning out to be much more complex. Evidence is accumulating that several
different genetic loci may play a role in Wilms' tumour … isolated predisposition gene (WT1) are …
different genetic loci may play a role in Wilms' tumour … isolated predisposition gene (WT1) are …
Wilms' tumours: about tumour suppressor genes, an oncogene and a chameleon gene
V Huff - Nature Reviews Cancer, 2011 - nature.com
… crucial gene alterations, this has not been the case. Mutations in Wilms tumour 1 (WT1), Wilms
tumour gene … In summary, the known genetic alterations that occur in Wilms' tumours are …
tumour gene … In summary, the known genetic alterations that occur in Wilms' tumours are …
Pathology, genetics and cytogenetics of Wilms' tumour
RM Zin, A Murch, A Charles - Pathology-Journal of the RCPA, 2011 - journals.lww.com
… Recent techniques in genetic analysis have improved our ability to characterise changes
in genes involved in WT which include WT1, CTNNB1, IGF2 and WTX. These genetic events …
in genes involved in WT which include WT1, CTNNB1, IGF2 and WTX. These genetic events …
Wilms tumor genetics
V Huff - American journal of medical genetics, 1998 - Wiley Online Library
… tion genes, a role for other genes in the development of WTs is implied by the somatic
occurrence of genetic … Determining the pattern of presence or absence of these various genetic …
occurrence of genetic … Determining the pattern of presence or absence of these various genetic …
The molecular biology of Wilms' tumour
… 11 are needed for Wilms’ tumour to develop. Gross genetic changes affecting this part of …
(‘A’ in this figure) that lies close to the tumour suppressor gene. The first hit is usually a point …
(‘A’ in this figure) that lies close to the tumour suppressor gene. The first hit is usually a point …
Molecular nature of genetic changes resulting in loss of heterozygosity of chromosome 11 in Wilms' tumours
… of genetic changes in chromosome 11 in Wilms' tumours. Using a range of probes for regions
11p15, 11p13 and llq we have screened DNA from 14 Wilms' tumours … Wilms' tumours. In …
11p15, 11p13 and llq we have screened DNA from 14 Wilms' tumours … Wilms' tumours. In …
Wilms tumor: an update
T Al-Hussain, A Ali, M Akhtar - Advances in anatomic pathology, 2014 - journals.lww.com
… In addition to WT1 and WT2 genes, a range of additional genes have been implicated in
the pathogenesis and biology of WT. These genes may not be involved in the early stages of …
the pathogenesis and biology of WT. These genes may not be involved in the early stages of …
Molecular genetics of Wilms' tumour
JSH Tay - Journal of paediatrics and child health, 1995 - Wiley Online Library
… often associated with bilateral Wilms’ tumour than is aniridia,12 suggesting a tighter linkage
between these genes than that between the aniridia and Wilms’ tumour genes. The fourth …
between these genes than that between the aniridia and Wilms’ tumour genes. The fourth …
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