… , very few CHD-causing genes have been identified so far. Molecular and genetic analysis
of heart development—which requires the execution of specific genetic programs—has led to …

… development (http://research.bmn.com/mkmd ). The complexity of genetic control of heart
development … that harbor mutations in genes that are essential for cardiac development (Yelon, …

… as gene-targeted clinical management. This review summarizes our current understanding
of the molecular basis of normal heart development and … of embryonic heart development, we …

… cardiac development and the pathogenesis of cardiac malformations are being made. Here
we review congenital heart disease due to single gene defects identified by human genetic …

… In the last 40 years, several studies have demonstrated that tissues of extracardiac origin are
crucial for normal heart development. The discovery of the so-called ‘secondary heart field’ (…

… it possible to sequence the entire genome or all genes (whole exome sequencing). This …
highlight new insights and recent developments in the understanding of genetic syndromes …

… few insights into the genes responsible foratrial chamber maturation. This is especially
noteworthy relative to the numberof genes … for this relative lack of genetic insight.First, atrial septal …

… genes involved in heart development and cardiomyocyte function, including those implicated
in CHD. Surprisingly, despite the strong conservation of TFs that drive heart development …

… of novel animal models of cardiovascular development and disease are providing ever more
insight into cardiovascular diseases and development, and bring closer the prospect of ‘post…

… Insight has come from studies in … a genetic blueprint for heart development, and consider
how perturbations of cardiac developmental control genes may result in different forms of heart …