… factors than are late-onset IBD patients. If genetic susceptibility is greater, then pediatric IBD
patients can be expected to have a higher frequency of the gene mutations. The purpose of …

… more than 30 distinct genomic loci involved in the genetic susceptibility to Crohn's disease
(CD). These loci encode genes involved in a number of homeostatic mechanisms: innate …

… presence of genes common to both diseases, and … IBD Genetics Consortium (IIBDGC)
demonstrating that highly significant associations with CD could also confer genetic susceptibility …

… genetic data (4). In this review I will summarise recent clinical studies on … genetic
predisposition to Crohn’s disease and focus on the clinical characteristics of familial Crohn’s disease…

… The main merit of genetic studies in IBD so far has been the translation from the identification
of Crohn's disease susceptibility loci to pathways important for disease pathogenesis. …

… forms of inflammatory bowel disease (IBD). The exact causes of Crohn's disease are unknown,
… microbiota in genetically susceptible individuals [2]. There is currently no known cure and …

… of the role of genetics in IBD is to preliminary to justify the exclusion of a patient with a positive
family history for IBD or with proven genetic susceptibility factors from stem cell donation. …

… genetically susceptible host. It was estimated that 20% to 30% of CD patients carry an
abnormal variant in NOD2 and the penetrance of NOD2 is not more than 5% and 0.5% for carrying …

… genetics in the progression of Crohn's disease (CD) is unclear. … Crohn's disease (CD) is a
chronic inflammatory disorder of the … Disease phenotype has previously been characterized …

… disease 18 . To better understand the genetic contribution to prognosis in Crohn's disease,
we performed a within-cases GWAS in two Crohn's disease cohorts and performed meta-…