… only a susceptibility gene, but also a disease-modifier gene for Crohn’s disease.
Enriching … a susceptibility variant for Crohn disease in ATG16L1. Nat Genet. 2007;39:207–211. …

… SNPs identifies a susceptibility variant for Crohn disease in … SNPs identifies a susceptibility
variant for Crohn disease in … have been identified in the gene ATG16L1, highlighting the SNP …

… Crohn's disease is a disorder mediated by Tlymphocyteswhich arises in genetically susceptible
individuals as a result of a breakdown in the regulatory constraints on mucosal immune …

… A “working model” of the pathophysiology of Crohn's disease (CD) is of an abnormal
immune response to enteric bacteria in genetically susceptible individuals. There is a greater …

Background Autophagy and regulation of IL-23 signaling pathways have been implicated in
the pathogenesis of Crohn's disease (CD). We studied the mode of inheritance and …

… in IBD.' A linkage analysis of chromosome 6 loci in familial aggregations of Crohn's disease
(… or genetic heterogeneity.2 However, this finding does not exclude the possibility that HLA …

Background A German genome-wide nonsynonymous single nucleotide polymorphism (nsSNP)
association study identified ATG16L1 as a Crohn's disease (CD) susceptibility gene. …

… (VAT) and its interaction with genetic predisposition in Crohn's disease (CD) progression. …
of disease onset, little is known about the role of environmental and genetic factors in disease …

… bowel disease (IBD)—Crohn's disease (CD) and … genetic background. Using a three-stage
design, we performed a functional candidate-gene analysis of innate immune pathway in IBD. …

… Crohn's disease might result from a complex interplay between genetic susceptibility,
environmental factors, and altered gut microbiota, leading to dysregulated innate and adaptive …