… genetic variation associated with addiction. We found that 72%-98% of addiction-associated
genetic variants lie in … Of those risk variants, 47%-85% lie in introns, which is a substantial …

… (GWASs), genetic variant associations were not substantially … variants, that are associated
with a disease. Unfortunately, SNPs explain only a part of the variance in substance addiction …

… As in studies of other complex phenotypes, studies were conducted on relatively modestly
sized samples and single gene variants, genes or haplotypes were examined with exonic …

… common gene variants with small effects, non-linear interactions between genetic variants
(… at expanding our understanding of the neurobiology underlying drug addiction while, at the …

… We describe imaging genetics and discuss the utility of its application to addiction. We then
… as an example of how genetic variation may lead to variation in behavioral phenotype. Finally…

… Genetic variants in CYP2B6 that affect the rate of bupropion metabolism have been identified.
Therapeutic drug monitoring of hydroxybupropion or CYP2B6 genotyping could be useful …

… Due to the complex nature of drug addiction, our greatest understanding of the neurobiological
aspects of processes mediating addictive behaviours have, to date, largely come from …

… specific addictions. These gene variants may function synergistically with genetic polymorphisms
… Addictions can also be comorbid with major infectious disorders, such as HIV/AIDS (4). …

… Genes influencing diverse aspects of addiction neurobiology … the genetic heterogeneity
model, different genetic variants … individuals, but a single genetic variant can suffice. In twin …

… DNA variations (ie, polymorphisms) at specific locations on the chromosomes result in gene
variants (ie, alleles) that differ in their function or activity and thereby may increase or reduce …