… genes and syndromes associated with predisposition to colorectal cancer (CRC), with an
overview of gene variant … Germline pathogenic variants in genes conferring high or moderate …

… It is estimated that genetic variants explain 12–35% of the heritability in colorectal cancer
(CRC) risk (Lichtenstein et al. 2000; Czene et al. 2002; Jiao et al. 2014). To date, Genome-…

… Here, we summarize the recent GWASs related to newly identified genetic variants associated
with CRC risk and clinical outcome. The findings from these studies suggest that there is a …

… with colorectal cancer. Seven hundred seventy-six patients with surgically resected colorectal
adenocarcinoma … between GWAS-identified genetic variants and the clinical outcomes of a …

… variant hypothesis, a majority of the heritability in CRC may be explained by multiple common
genetic variants with … The common disease-common variant hypothesis has been recently …

… All patients with histologically confirmed colorectal adenocarcinoma were enrolled with a
response rate of 93%. The detailed diagnosis of CRC patients was previously described (22). …

… All cases were newly diagnosed on the time of enrollment without restrictions of age and
sex and have been histologically confirmed to be colorectal adenocarcinoma. The controls …

… carcinomas and eight colorectal poorly differentiated … a colorectal adenocarcinoma-specific
panel comprising 196 amplicons covering 32 genes linked to colorectal adenocarcinoma, …

… TNFAIP3 gene is frequently deleted in colorectal adenocarcinomas, leading to lower gene …
Together with our data, this proposes that TNFAIP3 N102S may be a germline genetic variant …

… Our ongoing molecular epidemiology colorectal cancer study of Austria (CORSA) is nested
within this screening project. Genetic variation in TERT gene and interindividual variability in …