… Quantitatively, our model predicts the total numbers of genetic variations in CYP genes to
be around 4.8×10 4 and 3.4×10 4 in one million individuals of African or European ancestry, …

… CYP is influenced by a unique combination of mechanisms and factors including genetic …
variants exist and that additional variants in regulatory genes or in NADPH:cytochrome P450 …

… Some of these genes are highly polymorphic with multiple alleles and the prediction of … CYP
genes that are important for drug metabolism is instrumental in drug therapy [8]. The genetic …

… Investigations of the genetic variation of CYP2A6 and its … about CYP2A6 , its genetic variants
and their clinical consequences. … To date, 57 known human CYP genes and 29 known CYP …

… % of total CYP content of … gene interaction, and common genetic variations in the sequence
encoding drug transporters, drug receptors, target genes and other pharmacodynamic genes …

… 31 in CYPs and 65 in ALDHs) (Tables 2 and 3, respectively). Among the 906 genetic variations
identified … , 627 (69%; 157 in CYPs and 470 in ALDHs) had not been reported previously. …

… The CYP and PON genes have essential response to both endogenous and exogenous
signals through gene expression or metabolism pathways. Pregnane X receptor (PXR) is the …

… Genetic variation affecting drug bioavailability has been most clearly demonstrated for
genes in the CYP … Studies have investigated the genetic basis of several individual drug-CYP …

… a variation of one enzyme has no influence over the activity of others. Clinical relevance of
genetic variability in CYP genes … Close relations between CYP isoenzymes and drug adverse …

… Detection of genetic variations in CYP genes can be used to predict the phenotype and
thereby suffice to optimize drug treatment. Various approaches to investigate SNPs have been …