… Some heritable changes in the expression of these genes, which are not associated with
inheritance of an altered genetic code, encompass their epigenetic modulation [44, 94]. …

… Unlike genetic mutations, aberrations in epigenetic processes are reversible, which opens
the possibility for novel pharmacological treatments. Non‑coding RNAs (ncRNAs) represent …

… of the epigenetics associated with PAH pathobiology and discuss the possible epigenetic
modulations … In particular, several human genetic mutations have been closely linked with …

… Genetic mutations can explain the cause of gene loss over evolutionary time, but many silencing
phenomena may be epigenetically … unknown, one possibility is modulation of a few key …

… Indeed, multiple genetic changes in the TP53 gene have been detected in various
inflammatory tissues such as IBD,53, 54 Barrett's esophagus, 55 and HCV-associated chronic …

… in chromatin, thereby modulating gene expression at different … An important aspect of
epigenetic gene silencing by aberrant … such changes can predispose to genetic changes (mutations…

… modulations through epigenetic mechanisms. As a key and central component of epigenetic
… Alterations in DNA methylation profiles can lead to changes in gene expression, resulting in …

… DNA sequence variation, with epigenetic modifications being … of genetic variants through
environmental modulation [110,… genetic changes, further obscuring the link between genetics …

… of genetic variants associated with gene expression changes … could have an impact on
modulating disease risks.33 This way, … ,122 which showed that modulating the environment and …

… genes. As it is well known that several tumor suppressor genes are silenced in cancer by
epigenetic … to their aberrant epigenetic landscape and consequently become more sensitive to …