Genetic variations and epigenetic modulations in CYP genes: Implications in NSAID-treatment of arthritis patients

SR Chowdhury, OD Gupta, AK Ghosh, PS Singha… - The Nucleus, 2021 - Springer
… to individuals with the wild type CYP gene (CYP2C9*1). There are … in NSAID treated patients
with genetic polymorphism. In this review, complications associated with the use of NSAIDs

Pharmacogenetics and pain treatment with a focus on non-steroidal anti-inflammatory drugs (NSAIDs) and antidepressants: a systematic review

F Zobdeh, II Eremenko, MA Akan, VV Tarasov… - Pharmaceutics, 2022 - mdpi.com
… three major drug groups used for pain treatment (ie, NSAIDs, TCAs, SSRIs that fulfilled …
genetic variation in CYP2C9 and CYP2C8 only have a very modest influence on the ibuprofen

Genetically mediated interindividual variation in analgesic responses to cyclooxygenase inhibitory drugs

YS Lee, H Kim, TX Wu, XM Wang… - Clinical Pharmacology …, 2006 - Wiley Online Library
… efficacy of nonsteroidal anti-inflammatory drugs and selective … genetic variations to predict
patient risk and benefit to drugs. … from ibuprofen (P = .001) and rofecoxib (P = .049) treatment

Variability in analgesic response to non-steroidal anti-inflammatory drugs

KN Theken - Prostaglandins & other lipid mediators, 2018 - Elsevier
… to NSAIDs, reflecting the complex interplay between mechanisms of pain, differences between
distinct NSAIDs, and patient-specific factors such as genetic variation… to NSAID treatment. …

Genetic variants in COX-2, non-steroidal anti-inflammatory drugs, and breast cancer risk: the Western New York Exposures and Breast Cancer (WEB) Study

TM Brasky, MR Bonner, KB Moysich… - … research and treatment, 2011 - Springer
… Better understanding of the role of COX-2 genetic variation and interaction with NSAID use
… Although few have reported on interaction of COX-2 variation with individual NSAIDs, our …

Genetic variation in UGT genes modify the associations of NSAIDs with risk of colorectal cancer: Colon cancer family registry

D Scherer, LM Koepl, EM Poole… - Genes …, 2014 - Wiley Online Library
gene approach with the aim of assessing the association of the complex genetic variation
within UGT1A and UGT2B gene … risk and effect modification of NSAID use on colorectal cancer. …

Genetic variation in cyclooxygenase 1: effects on response to aspirin

MK Halushka, LP Walker… - Clinical Pharmacology & …, 2003 - Wiley Online Library
… nonselective nonsteroidal anti-inflammatory drugs (NSAIDs). ASA and other NSAIDs exert
some … the role of genetic variation in COX-1 relative to the function of the gene by measuring …

Variability of the drug response to nonsteroidal anti-inflammatory drugs according to cyclooxygenase-2 genetic polymorphism

SJ Lee, MK Park, DS Shin, MH Chun - Drug design, development …, 2017 - Taylor & Francis
… Celecoxib, a type of NSAID designed for COX-2 inhibition that is used clinically to treat
COX-2 with tumorigenesis are not predictable, the genetic variations in COX-2 are a remarkable …

Genetic variants in cyclooxygenase-2 contribute to post-treatment pain among endodontic patients

E Applebaum, AG Nackley, E Bair, W Maixner… - Journal of …, 2015 - Elsevier
treatment endodontic pain remains unknown. Animal studies indicate that genetic variations
… may ultimately improve the safe and effective use of NSAIDS by better tailoring drug dosage …

Influence of genetic polymorphisms on the response to tramadol, ibuprofen, and the combination in patients with moderate to severe pain after dental surgery

M Saiz-Rodríguez, S Valdez-Acosta, AM Borobia… - Clinical Therapeutics, 2021 - Elsevier
… Tramadol (TRA) and ibuprofen (IBU) belong to opioid and nonsteroidal anti-inflammatory
drug (NSAID) families, respectively, which are widely used for the treatment of pain in clinical …