… as a novel mechanism for generating phenotypic diversity driven by genomic plasticity. …
how mosaic aneuploidy in Leishmania may occur and how it may have major genetic and …

… FISH enables not only the direct observation of aneuploid Leishmania cells but, more
importantly, that of the mosaic structure of the strain population. The principle of the technique is …

… mutations in a miltefosine transporter gene, while aneuploidy changes only emerge later, …
and genome plasticity are hallmarks of parasite adaptation, but the scenario of aneuploidy …

… In summary, aneuploidy within the Leishmania genome allows for drug resistance and
adaptation to the environment, as exemplified from data derived from a multitude of studies. …

… remarkable genomic plasticity (14,18). The Leishmania genome is generally considered to
be diploid, although all Leishmania genomes analyzed hitherto display aneuploidy affecting …

… genome flexibility of chromosomal ends of the leishmanial … , we discuss the plasticity of
Leishmania genome organization … causes of such genome plasticity which includes aneuploidy, …

… 69% of the individuals aneuploid for one or more chromosomes [… Leishmania constitutively
displays mosaic aneuploidy across … [4] further support mosaic aneuploidy as a general feature …

… that aneuploidy seems to be the norm 58– 64 . Within populations of Leishmania parasites,
distinct aneuploidy … This phenomenon was called mosaic aneuploidy and can translate into a …

… Recent analyses of Leishmania genomes have shown that aneuploidy is more widespread
in this genus than previously assumed (Figure 1). The chromosome copy numbers of two …

… 7 , and its remarkable genomic plasticity 8 . The genome of Leishmania sp is ubiquitously
aneuploid, and high levels of chromosomal somy variation, as well as local gene copy number …