… genome sequencing (WGS) to transform tuberculosis (TB) diagnostics, when the then recent
use of “next generation” sequencing … (XDR) isolates of Mycobacterium tuberculosis was …

… completion of the genome sequence of Mycobacterium tuberculosis (MTB), and with the
advent of next generation sequencing technologies (NGS), whole-genome sequencing (WGS) …

… Whole genome sequencing (WGS) of Mycobacterium tuberculosis has rapidly progressed
from a research tool to a clinical application for the diagnosis and management of tuberculosis …

… In a retrospective observational study, we used Illumina technology to sequence M tuberculosis
genomes from an archive of frozen cultures. We characterised isolates into four groups: …

… -genome sequencing (… sequence a complete bacterial genome for US$500 or less. Many
studies have addressed questions about tuberculosis with WGS, and knowing the sequence of …

… Moreover, technological constraints mean that only a few genomic loci can be
simultaneously investigated [4]. Sanger DNA sequencing, developed in the 1970s, enabled …

… We highlight how analysis of M. tuberculosis whole genome sequence data could routinely
provide guidance for individual … We also look at challenges or barriers to application of M. …

… of highly resistant Mycobacterium tuberculosis. Whole-genome sequencing provides …
conventional molecular tests, this has previously been achievable only from cultures of M. …

… With the rapid development of whole genome sequencing (WGS) technologies, we have
unprecedented capacity to detect genetic diversity in Mycobacterium tuberculosis (Mtb). WGS is …

… -genome sequencing to characterise common and rare mutations predicting drug resistance,
or consistency with susceptibility, for all first-line and second-line drugs for tuberculosis. …