[HTML][HTML] Genomic alterations at the basis of treatment resistance in metastatic breast cancer: Clinical applications

A Toss, F Piacentini, L Cortesi, L Artuso, I Bernardis… - Oncotarget, 2018 - ncbi.nlm.nih.gov
The standard of care for breast cancer has gradually evolved from empirical treatments
based on clinical-pathological characteristics to the use of targeted approaches based on the …

Clinical applications of genomic alterations in ATLL: predictive markers and therapeutic targets

N Yoshida, H Miyoshi, K Ohshima - Cancers, 2021 - mdpi.com
… In this review we summarize the genomic alterations of ATLL, focusing on differences between
geographic regions and ages at onset. We also present genomic alterations reported by …

The emerging clinical relevance of genomics in cancer medicine

MF Berger, ER Mardis - Nature reviews Clinical oncology, 2018 - nature.com
… preclinical discovery and clinical application should improve … approaches that combine
genomic and clinical data, and … entire genome), the different types of genomic alterations that …

[HTML][HTML] Genomic alterations in cholangiocarcinoma: clinical significance and relevance to therapy

M Carotenuto, A Sacco, L Forgione… - Exploration of targeted …, 2022 - ncbi.nlm.nih.gov
genomic alterations. In this review article, the current knowledge about genomic alterations
… NGS testing of cfDNA, can have clinical applications in patients with CCA. In addition to …

Clinical application of array-based comparative genomic hybridization for the identification of prognostically important genetic alterations in chronic lymphocytic …

RA Higgins, SR Gunn, RS Robetorye - Molecular Diagnosis & Therapy, 2008 - Springer
… of array CGH as a clinical tool for the identification of genomic alterations with prognostic
significance in CLL, and suggest ways to integrate this test into the clinical molecular diagnostic …

[HTML][HTML] Genomic and epigenomic alterations in cancer

BVSK Chakravarthi, S Nepal, S Varambally - The American journal of …, 2016 - Elsevier
genomic alterations include copy number variations, including amplification or deletion of
the genomic … Apart from identifying multiple genomic alterations in cancer, the high-throughput …

Genomic alteration–driven clinical trial designs in oncology

R Simon - Annals of Internal Medicine, 2016 - acpjournals.org
genomic alteration. In these cases, phase 2 trials may be restricted to patients whose tumor
carries the genomic alteration … based on a defined genomic alteration rather than on primary …

[HTML][HTML] Genomic alterations in hepatocellular carcinoma and their clinical application to genomic medicine

T Imamura, Y Okamura - Hepatobiliary Surgery and Nutrition, 2022 - ncbi.nlm.nih.gov
… Recent large-scale genomic … to clinical practice. Based on the latest findings, we will
describe the overall landscape of genomic alterations in HCC and their application to genomic

Genomic instability in pluripotent stem cells: implications for clinical applications

SE Peterson, JF Loring - Journal of Biological Chemistry, 2014 - ASBMB
… FIGURE 1Common genomic alterations in hPSCs. High-resolution SNP analysis was
performed on 186 pluripotent (both hESC and hiPSC samples) and 119 non-pluripotent samples. …

Oncogenic genomic alterations, clinical phenotypes, and outcomes in metastatic castration-sensitive prostate cancer

KH Stopsack, S Nandakumar, AG Wibmer… - Clinical Cancer …, 2020 - AACR
genomic features that are associated with clinical phenotypes, including with disease volume.
We identify genomic alterations … resistance), demonstrating that alterations in AR, TP53, …