Genomic basis of atrial fibrillation

A Bapat, CD Anderson, PT Ellinor, SA Lubitz - Heart, 2018 - heart.bmj.com
… throughout the genome for association … Atrial Fibrillation Genetics Consortium or AFGen,
and included about 18 000 individuals with AF and over 1 00 000 without, in which 23 genomic

Genetics of atrial fibrillation in 2020: GWAS, genome sequencing, polygenic risk, and beyond

C Roselli, M Rienstra, PT Ellinor - Circulation research, 2020 - Am Heart Assoc
… in identifying the genetic basis for this common condition. In … for atrial fibrillation, including
linkage studies, genome-wide … and future directions for atrial fibrillation genetics research. …

[HTML][HTML] Genetic basis of atrial fibrillation

O Campuzano, A Perez-Serra, A Iglesias, R Brugada - Genes & diseases, 2016 - Elsevier
Atrial fibrillation is the most common sustained arrhythmia and remains … A better understanding
of the genetic basis will induce … have focused on current genetics basis of atrial fibrillation. …

New advances in the genetic basis of atrial fibrillation

S Mahida, PT Ellinor - Journal of cardiovascular …, 2012 - Wiley Online Library
New Genetic Loci for Atrial Fibrillation. Over the past decade, compelling evidence has emerged
from population‐based studies to suggest that AF is a heritable disease. More recently, …

The molecular genetic basis of atrial fibrillation

X Huang, Y Li, J Zhang, X Wang, Z Li, G Li - Human Genetics, 2020 - Springer
… genetic basis of AF genomics from the literature and discuss the results of recent genomic
analysis and future directions for the field. A better understanding of AF genetic basis could …

Biobank-driven genomic discovery yields new insight into atrial fibrillation biology

JB Nielsen, RB Thorolfsdottir, LG Fritsche, W Zhou… - Nature …, 2018 - nature.com
… In summary, we substantially increased the number of genome-wide significant risk variants
for atrial fibrillation through a large GWAS meta-analysis. We highlighted genes important …

Genetics of atrial fibrillation: from families to genomes

IE Christophersen, PT Ellinor - Journal of human genetics, 2016 - nature.com
Atrial fibrillation (AF) is the most common cardiac rhythm disorder and the prevalence is
increasing. The disease confers an increased risk of severe complications such as heart failure, …

Epigenetic and transcriptional networks underlying atrial fibrillation

AF van Ouwerkerk, AW Hall, ZA Kadow… - Circulation …, 2020 - Am Heart Assoc
Genome-wide association studies have uncovered over a 100 genetic loci associated with
atrial fibrillation (AF), the most common arrhythmia. … regions of the genome where causal …

The genetic basis of coronary artery disease and atrial fibrillation: A search for disease mechanisms and therapeutic targets

J Neelankavil, CD Rau, Y Wang - Journal of Cardiothoracic and …, 2015 - jcvaonline.com
… In genome-wide association studies (GWAS), SNPs commonly are used as the basis of
genotyping. Distribution of SNP genotypes across the entire genome in the cases versus controls …

Atrial fibrillation: current knowledge and future directions in epidemiology and genomics

JW Magnani, M Rienstra, H Lin, MF Sinner, SA Lubitz… - Circulation, 2011 - Am Heart Assoc
… Circos 120 plot representing the genetic variants found by genome-wide association study
for atrial fibrillation (AF) and AF risk factors. The outer ring represents the chromosomes; the …