Genomic instability and cancer: lessons learned from human papillomaviruses
N Korzeniewski, N Spardy, A Duensing, S Duensing - Cancer letters, 2011 - Elsevier
… Nonetheless, cell populations with increased genomic plasticity may gain … human
papillomavirus (HPV)-associated neoplasms are an excellent model system to study genomic …
papillomavirus (HPV)-associated neoplasms are an excellent model system to study genomic …
Human papillomavirus and genome instability: from productive infection to cancer
B Prati, B Marangoni, E Boccardo - Clinics, 2018 - SciELO Brasil
… , it is clear that human papillomavirus-transformed … human papillomavirus infection on DNA
repair mechanisms. In addition, we discuss the potential of exploiting human papillomavirus-…
repair mechanisms. In addition, we discuss the potential of exploiting human papillomavirus-…
Human papillomaviruses and centrosome duplication errors: modeling the origins of genomic instability
S Duensing, K Münger - Oncogene, 2002 - nature.com
… Human papillomaviruses and genomic instability Genomic instability is frequently
observed in HPV-associated cervical cancer as well as in many other human malignancies (reviewed …
observed in HPV-associated cervical cancer as well as in many other human malignancies (reviewed …
Mechanism of genomic instability in cells infected with the high-risk human papillomaviruses
M Kadaja, H Isok-Paas, T Laos, E Ustav… - PLoS …, 2009 - journals.plos.org
… ” human papillomaviruses (HPVs) are frequently found integrated into the cellular genome.
… of viral replication proteins could induce genomic instability in the cells with integrated HPV. …
… of viral replication proteins could induce genomic instability in the cells with integrated HPV. …
[HTML][HTML] Genomic instability induced by human papillomavirus oncogenes
JJ Chen - North American journal of medicine & science, 2010 - ncbi.nlm.nih.gov
… Human papillomavirus (HPV) infection is necessary but not sufficient for the development of
cervical cancer. Genomic instability … Genomic instability in the form of polyploidy has been …
cervical cancer. Genomic instability … Genomic instability in the form of polyploidy has been …
Genomic instability and DNA damage repair pathways induced by human papillomaviruses
T Kono, L Laimins - Viruses, 2021 - mdpi.com
Human papillomaviruses (HPV) are the causative agents of cervical and other anogenital
cancers as well as those of the oropharynx. HPV proteins activate host DNA damage repair …
cancers as well as those of the oropharynx. HPV proteins activate host DNA damage repair …
The drivers, mechanisms, and consequences of genome instability in HPV-driven cancers
… human papillomaviruses (HPV) can accumulate DNA damage and eventually transform into
HPV-driven cancers. Genome instability… themselves affect genome instability. While the HPV …
HPV-driven cancers. Genome instability… themselves affect genome instability. While the HPV …
Recent insights into the control of human papillomavirus (HPV) genome stability, loss, and degradation
C Fisher - Journal of clinical medicine, 2015 - mdpi.com
… Catalytically inactive ATM causes genomic instability and embryonic lethality in mice
demonstrating the importance of additional, poorly understood roles for ATM beyond its kinase …
demonstrating the importance of additional, poorly understood roles for ATM beyond its kinase …
Genome-wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability
K Akagi, J Li, TR Broutian, H Padilla-Nash… - Genome …, 2014 - genome.cshlp.org
… Genomic instability is a hallmark of human cancers, including the 5% caused by human
papillomavirus (HPV). Here we report a striking association between HPV integration and …
papillomavirus (HPV). Here we report a striking association between HPV integration and …
Beta human papillomavirus E6 expression inhibits stabilization of p53 and increases tolerance of genomic instability
NA Wallace, K Robinson, DA Galloway - Journal of virology, 2014 - Am Soc Microbiol
… also contribute to the tolerance of genomic instability through p53-independent mechanisms…
E6 proteins would also increase the tolerance of genomic instability in p53-dependent ways. …
E6 proteins would also increase the tolerance of genomic instability in p53-dependent ways. …
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