… In this Review, we examine the opportunities and challenges that accompany the shift to
genomic medicine for the diagnosis of genetic diseases of the kidney and urinary tract. We …

… of renal disease have deepened our understanding of progressive kidney disease. Here, …
importance to progressive glomerular disease that result in end-stage kidney disease (ESKD). …

… As genomic medicine is increasingly incorporated into mainstream medical practice, more
… Functional genomics involves the iPSC in modelling kidney disease, leveraging local …

… Conceptually, monogenic kidney diseases with very rare but very highly penetrant genetic …
in the genome fall at opposite ends of the spectrum of inherited kidney diseases. Identification …

… used genomic medicine methods. Then, we summarize the potential genomic biomarker …
, we discuss the opportunities and challenges offered by personalized genomic medicine. …

… approaches to identify biomarkers for kidney disease. In this review, we have summarised
the most important studies in humans investigating genomic biomarkers for CKD in the last …

Chronic kidney disease is a long-term condition with significant implications for quality of life
and health care costs. To uncover the etiology in selected cases suspected of monogenicity, …

… in England can be referred through the NHS Genomic Medicine Service. Testing is useful for
… of inherited kidney diseases commonly encountered in the clinic and how genomic testing …

… genomic medicine services, such as in the UK, will lead to increased availability of genomic
… A significant proportion of paediatric kidney disease is due to single gene changes inherited …

… , and hence the clinical value of genomic testing, both to the … genomic tests in renal patients
13,14 or evaluated research-based genomic tests in particular subgroups of kidney disease …