Genotoxic effects of fluoride: a controversial issue

Y Li, AJ Dunipace, GK Stookey - Mutation Research/Reviews in Genetic …, 1988 - Elsevier
… Attempts to induce meiotic abnormalities in mouse oocytes in vivo with acute (500/~g NaF,
single iv) or chronic (250/~g NaF, sc for 16 days) fluoride exposure failed to produce …

Putative mechanisms of genotoxicity induced by fluoride: a comprehensive review

DA Ribeiro, VQ Yujra, VHP da Silva… - … Science and Pollution …, 2017 - Springer
… By comparison, others have yet mentioned that fluoride exposure generates reactive
oxygen species (ROS) by SIRT1/autophagy induction through c-Jun N-terminal kinase (JNK) …

Genotoxic effect and rat hepatocyte death occurred after oxidative stress induction and antioxidant gene downregulation caused by long term fluoride exposure

FD Campos-Pereira, L Lopes-Aguiar… - Chemico-biological …, 2017 - Elsevier
… to investigate genotoxic potential of fluoride. The … genotoxic potential of fluoride but did not
confirm mitochondrial swelling nor an increase of positive TUNEL labelling induced by fluoride

Genotoxic evaluation of chronic fluoride exposure: sister-chromatid exchange study

Y Li, W Zhang, TW Noblitt, AJ Dunipace… - Mutation Research …, 1989 - Elsevier
… As part of a continuing investigation, this study was conducted to examine the genotoxic
effects of chronic exposure to sodium fluoride (NaF) in drinking water on the frequency of sister-…

Genotoxic evaluation of chronic fluoride exposure: micronucleus and sperm morphology studies

AJ Dunipace, W Zhang, TW Noblitt… - Journal of Dental …, 1989 - journals.sagepub.com
… The purpose of this study was to investigate the genotoxic effects of chronic fluoride exposure
on mammalian cells in vivo by use of the mouse bone-marrow micronucleus test and the …

Investigation of the genotoxic effects of fluoride on a bone tissue model

VP Volobaev, ES Serdyukova, EE Kalyuzhnaya… - Toxicological …, 2020 - Springer
… exert genotoxic effects on bone cells indirectly indicates the possible importance of fluoride
… hypothesis, an experimental assessment of the genotoxic effects of fluoride-ion exposure on …

A review on fluoride induced organotoxicity and genotoxicity in mammals and zebrafish

A Dey Bhowmik, A Chattopadhyay - The nucleus, 2019 - Springer
… , chronic fluoride exposure beyond the permissible limit causes detrimental effect on soft …
Studies also indicate that fluoride induces significantly genotoxic effect both in vivo and in …

Genotoxic effects of fluoride evaluated by sister-chromatid exchange

Y Li, NA Heerema, AJ Dunipace, GK Stookey - Mutation Research Letters, 1987 - Elsevier
genotoxic potential of fluoride (in the form of sodium fluoride, … Fluoride analysis of the culture
medium demonstrated that it … indigenous fluoride, and the concentration of added fluoride

Effects of long-term fluoride exposure are associated with oxidative biochemistry impairment and global proteomic modulation, but not genotoxicity, in parotid glands …

GHN Miranda, L Alencar de Oliveira Lima… - Plos one, 2022 - journals.plos.org
… Thus, this study aimed to investigate the effects of long-term exposure to F on the parotid
salivary gland of mice, from the analysis of oxidative, proteomic and genotoxic parameters. …

Lack of effect of prior treatment with fluoride on genotoxicity of two chemical agents in vitro

DA Ribeiro, MEA Marques, DMF Salvadori - Caries research, 2007 - karger.com
… ability of fluoride to modulate the genotoxic effects induced by the oxidative agent hydrogen
… Chinese hamster ovary cells were exposed in culture for 1 h at 37C to sodium fluoride at 7–…