… of genotoxicity data on regulatory decisions, interpretation of positive findings with respect
to human risk, and the degree of quantitative risk assessment applied to genotoxicity data also …

… The genotoxicity risk characterization integrates the hazard … strand breaks) need to be
interpreted as to how they impact the … completes the integration of the hazard identification, dose-…

… In vivo genotoxicity tests play a pivotal role in genotoxicity testing batteries. They are used
… if potential genotoxicity observed in vitro is realised in vivo and to detect any genotoxic …

… Genotoxicity testing of substances is used to evaluate genetic hazards and to obtain infor…
Further testing is necessary: (a) if available positive genotoxicity data cannot be interpreted …

… approach to the evaluation and interpretation of genotoxicity data. Such an approach …
action and should therefore not be included in the core set for hazard identification. However, …

… interpretation of genotoxicity data. These are mainly rooted in the limited capability of standard
in vivo genotoxicity testing … The mainly hazard-oriented approach for regulating genotoxic …

… Clearly, the presence of a genotoxic agent in the body provides … measuring genotoxic
materials in blood or urine are agent specific. This may be limiting because a particular hazardous …

… to recommend appropriate strategies for the use and interpretation of genetic toxicology …
the IWGT strategy working groups, and provide initial recommendations for hazard assessment. …

… vitro genotoxicity tests and agreed approaches to the practical interpretation of current positives.
… The difficulty of interpretation of genotoxicity data, while much more pronounced when …

… The screening of protein binding capacity may be of great help to select adequate genotoxicity
assays and to interpret the results; protein arrays are in development to establish specific …