… Differentiation and selection of germinal center B cells. Model for affinity-based differentiation
of B cells in germinal center… B cells proliferate and hypermutate in the germinal center dark …

… Germinal centers (GCs) form in secondary lymphoid tissues … hypermutation, generating GC
B cells with increasing affinity … GC B cells differentiate into memory B cells and plasma cells …

… as the site where germinal center B cell and T follicular helper (Tfh) cell differentiation
initiates. For the first 2 days postimmunization, antigen-specific T and B cells remained confined …

… In this review, we examine the roles of GC cytokines in the context of cell differentiation. … of
B cell differentiation. Another group has demonstrated that transgenic B cells binding antigen …

… Importantly, BCR affinity for antigen influenced the B-cell fate choice. … B cells to differentiate
toward plasma cells, whereas lower affinity favored memory B cells or GC B-cell development…

… gene expression, mechanisms that drive selective retention of specific GC B cells, differentiation
into the PCs and memory B cells (MBCs) and the contribution of the GC response to anti-…

… pre-B cell to the small resting pre-B cell. Consequently, Irf4,8 −/− mice lack IgM + B cells due
to a block in B-cell differentiation at the pre-B cell … the generation of mature B cells, IRF4 and …

… affinity centrocytes are allowed to switch isotype; iii) CD40hgation inhibits plasmacytic
differentation of mature B lymphocytes; Iv) memory B cells preferentially differentiate into plasma …

… B cell subset with memory B cell features. To test the possibility that these cells could derive
from germinal center (GC) B cell … , differentiation, and phenotype of GC B cells after culturing …

… for optimal primary antibody responses, while reduced BCR signaling of low affinity clones
would promote GC B-cell differentiation for affinity maturation. However, subsequent studies …