… To study the biological relevance of the Akt/mTOR signaling pathway in GDM, we compared
the phosphorylation (p-) and total protein expression levels of Akt, mTOR, 4E-BP1, and …

… In this work, miR-29b mimics were able to reduce PI3K and Akt phosphorylation and MDA
content, increase SOD and CAT expression levels and relieve oxidative stress. There are no …

… Briefly, serial sections were incubated overnight with rabbit polyclonal antibodies against
phospho (p) AKT, pERK, pmTOR, pp70, p4EBP1(all from cell Signaling, Danvers, MA) or …

… Gestational diabetes mellitus refers to the phenomena in which no dose of … Currently,
gestational diabetes has become one of the most … : possible regulation by tyrosine …

… levels of total and phosphorylated forms of Akt, AMPK, TSC2, … infants with weights appropriate
for gestational age (AGA) … the levels of total and phosphorylated forms of Akt, AMPK, TSC2, …

… Akt and Erk phosphorylation in PHT cells (3-fold) and in villous explants (2-fold) in all groups
to a similar degree. In contrast to the peripheral maternal … in these pregnancy complications. …

… the insulin receptor to activate PI3K by phosphorylation, and PI3K can catalyze the transformation
of PIP2 into PIP3, thus activating the AKT by phosphorylation to sustain the balance in …

… gestational diabetes mellitus (GDM), or abnormal maternal conditions such as pregestational
maternal … 202 and p42 mapk phosphorylated at threonine 204; Akt: protein kinase B/Akt; …

… binds to tyrosine phosphorylated IRS allowing IR to tyrosine phosphorylate p85 and activate
… signaling proteins which phosphorylate and activate Akt. Akt activation is required for …

… involvement in gestational diabetes mellitus (GDM), a well … Akt activation phosphorylates
and activates the kinase PIKfyve which promotes EGFR degradation. Thus, Akt phosphorylation …