… We propose that, as a second event, activation of the classic, FcRγ-associated … , and IgA
immune complexes from IgA nephropathy patients induce FcαRI-dependent cell activation. This …

… factors activate podocytes either by glomerular filtration or by transportation via the post-…
c | Immunofluorescence image of a glomerulus showing heavy granular staining of IgA in the …

… In addition to strongly suggesting activation of C4 via the lectin pathway in a subpopulation
of patients with IgAN, our data indicate glomerular activation of C3 and C5b-9 via the …

… have increased numbers of circulating IgA1-positive B cells and activated Tα helper (T H )
cells, … Although the underlying mechanism of glomerular IgA1 deposition in IgA nephropathy …

… tion to the glomerular and interstitial hypercellularity and decreased renal function which
are characteristic of the subgroup of cases of IgA nephropathy involving crescent formation at …

… to IgA nephropathy … IgA nephropathy severity. Recently, we have also gained insight into
possible mechanisms that could link glomerular IgA deposition, complement activity, glomerular …

… Immunoglobulin A nephropathy (IgAN) is defined by the predominant deposition of IgA in the
glomerular … complement activation can influence the extent of glomerular injury. Mesangial …

… and glomerular and circulating markers of complement activation are established, the mechanism
of complement activation and contribution to glomerular … of complement activation may …

… Immunoglobulin A nephropathy (IgAN) is a glomerular disease mostly affecting the mesangium,
as prevalent IgA … , other glomerular components are involved and, when activated, they …

… IgA-CIC (B), and sC5b–9 (C) in patients with IgA nephropathy. Patients were divided into two
groups according to presence or absence of glomerular … for complement activation in IgA-N …