… glucagon signaling and played a role in α cell proliferation. These results indicate a hepatic
α islet cell axis where glucagon … L-glutamine, regulate α cell proliferation and mass via mTOR…

… in skeletal muscle cells (as they do not express the glucagon receptor), the proposed index
may therefore reflect the liver–alpha cell axis rather than a muscle–liver–alpha cell axis. …

… of glucagon appear to be mediated by a single glucagon receptor (30); therefore, it was
also possible to create another condition with lack of glucagon signaling, namely glucagon …

… The liver–α-cell axis. The liver–α-cell axis constitutes a feedback loop in which circulating
amino acids stimulate glucagon secretion from pancreatic α-cells and glucagon in turn controls …

… We hypothesized that disruption of glucagon receptor signaling would lead to an increased
… glucagon, eventually associated with compensatory proliferation of the pancreatic alpha-cells…

… constitute the molecular underlying mechanism(s) for a liver-alpha cell axis by which glucagon
regulates amino acid metabolism and plasma levels of amino acids control the secretory …

… of glucagon and GLP-1 receptors is essential for β cell secretory … glucagon secretion from
α cells, we used diphtheria toxin (DT)-induced destruction of proglucagon-producing α cells …

… Paradoxically, the pancreatic peptide glucagon has reemerged … The synthesis of glucagon
analogs that are biophysically … of glucagon biology and ironically recruited glucagon agonism …

… cells, inhibit glucagon secretion whereas low plasma glucose concentrations represent one
of the most potent glucagon … and glucagon from the pancreatic beta cells and alpha cells, …

… -dependent ureagenesis is in the healthy liver activated during meals and thereby ensures
normal secretory rates of glucagon via the liver–α-cell axis, in which glucagon controls amino …