… α-cell proliferation are largely ignored. We hypothesize that not only increased glucagon
secretion but also increased α-cell proliferation is responsible for the elevated glucagon levels …

… Exposure of rat AR42J cells to … cellular proliferation, followed by cessation of proliferation
and expression of the islet hormones, insulin, glucagon, and somatostatin, in up to 50% of cells …

… showed islet α-cell hyperplasia, it was confirmed that the absence of glucagon induces α-cell
proliferation. Gelling et al.8 also reported that in addition to glucagon, the pancreatic tissue …

… To identify postulated hepatic-derived circulating factor(s) responsible for α cell proliferation,
… glucagon signaling and found that proliferation of mouse, zebrafish, and human α cells was …

… of β-cell proliferation, and enhancement of β-cell survival suggests that we may soon be
one step closer to the elusive goal of preserving β-cell function and preventing β-cell failure in …

… also provide evidence that active Wnt signaling stimulates the proliferation of beta cells as
a dominant-negative TCF7L2 inhibits both basal and Exd4-stimulated INS-1 cell proliferation. …

… the signal transduction pathways implicated in the proliferative action of GLP-1, we used
specific inhibitors for different kinases known to mediate cell proliferation in … of cell systems (33). …

… signal in parallel to regulate β cell proliferation, a possibility requiring further studies. In contrast
to age-dependent loss of PDGFR expression and signaling … by adult human β cells to Ex-…

… by glucagon-like peptides-1 and 2 (GLP-1 and GLP-2), directly … signaling pathways coupled
to cell proliferation and apoptosis. GLP-1 receptor activation enhances β-cell proliferation …

… glucagon-like peptide 1 (GLP-1) induces pancreatic β-cell … PI 3-kinase signaling pathway to
promote β-cell growth remains … and promote β-cell proliferation through transactivation of the …