… These findings did, however, not translate into human islets implanted into mice despite
an observed alpha cell proliferation following pharmacological glucagon receptor inhibition [121]…

… Excess glucagon signaling may drive excess … for glucagon as a key driver of diabetes
pathophysiology (3). Consequently, there is considerable interest in blocking glucagon signaling …

… insulin receptor in glucagon-secreting InR1G cells promoted enhanced glucagon secretion
and … signaling in the regulation of α cell function in both normo- and hypoglycemic conditions. …

… kinase B phosphorylation and completely abrogated both cellular proliferation (p<0.05)
and protection from drug-induced cellular death (p<0.01) induced by glucagon-like peptide-1. …

… cell proliferation and inducing cell death. However, liraglutide only was able to stimulate cell
apoptosis, whereas glucagon seemed to induce cell … reduction in the proliferation rate (of …

… pathways as rapamycin eliminated the amino acid induced alpha cell proliferation.
Previous literature have linked glucagon receptor signaling to amino acid metabolism through …

… Glucagon-like peptide-1 (GLP-1) stimulates … β cell mass via activation of β cell proliferation
and islet neogenesis. We examined whether GLP-1 receptor signaling modifies the cellular …

… , using MIN6 cells and primary islets, that the glucose competence of these cells was …
We showed that GLP-1-induced primary β-cell proliferation was suppressed by Igf-1r gene …

… or specific antagonists induces α-cell hyperplasia and alleviates … δ-cell neogenesis via
stimulating cell proliferation and duct-… Moreover, the increased δ-cell mass might reduce β-cell …

… IGF-I is critical for the ability of GLP-2 to induce intestinal growth and activate crypt cell
proliferation and β-catenin signaling. Other SEMF-derived growth factors may induce …