… We propose a model wherein chronic stress results in glucocorticoid receptor resistance (…
In study 1, we assessed stressful life events, GCR, and control variables including baseline …

… need to carefully regulate exposure to glucocorticoids (2–5). The magnitude and duration of
stress responses are controlled in large part by glucocorticoid receptors (GR), which provide …

Purpose Chronic and persistent exposure to negative stress can lead to adverse consequences
on health. Particularly, psychosocial factors were found to increase the risk and outcome …

… Such repeated aggressions trigger a stress response, resulting in glucocorticoid release …
We bred mice with selective inactivation of the gene encoding the glucocorticoid receptor (GR) …

… Chronic stress is a major risk factor for the development of psychiatric diseases (de Kloet et
… Using mice with a conditional inactivation of the glucocorticoid receptor at the pituitary level, …

… The stress response is therefore finely tuned through a series of … of glucocorticoid
receptors (GRs) to the nucleus, including binding to the chaperone protein FKBP5 and receptor …

… Our results and working model, together with the literature on chronic stress, suggest that
the convergence between GR and BDNF pathways may be an important node of dysfunction in …

… glucocorticoid resistance can be environmentally induced has important implications for
management of stress… of prevention and management of chronic stress. The simultaneous …

… glucocorticoid receptor and mineralocorticoid receptor mRNA … the brains of chronically and
nonchronically-stressed starlings. … , glucocorticoid receptor mRNA expression in chronically-…

… This is thought to involve activation of glucocorticoid receptors in the brain. In the present …
glucocorticoid receptor blockade by mifepristone can normalize the effects of chronic stress on …