… the glucose hypothesis; the observations that support a common cause of diabetic complications
and … may mediate the development or progression, or both, of long-term complications. …

… of diabetic complications. Although many factors have been shown to contribute to these …
hypothesized that peripheral nerves and dorsal root ganglia in diabetic animals up-regulate …

… The current, prevalent hypothesis based on in vitro data is that glucose variability might play
… complications of type 1 diabetes (2). According to this view (2), intraday glucose variability …

… Prospective Diabetes Study published in 1998. Prevention of diabetic complications requires
… There are several equally defensible hypotheses on the roots of complications, including, …

… the course of diabetic vascular disease, more diabetics develop … directed at lowering the
blood glucose is associated with in… glucose might be responsible for diabetic vascular disease. …

… present review examines the hypothesis that controlling postprandial glucose level is an
important strategy in the prevention of cardiovascular complications associated with diabetes. …

… that either support or reject these hypotheses and suggest a third unifying hypothesis. …
diabetic complications in large groups of patients who had normal or near-normal blood glucose …

… between glucose fluctuations and diabetic complications (3). This … influencing glucose
fluctuations on diabetic complications in … (88) hypothesized that modulating hypoglycemia may …

… glycaemic control reduces the risk of diabetic complications, both micro and macrovascular.
… glucose levels in diabetic patients in order to minimize long-term diabetic complications. © …

… with the formation of diabetic complications. This new insight … in the development of diabetic
complications—increased polyol … hypothesis for the formation of diabetic complications (…