… synthesized GLUT4 into the specialized compartment. Insulin-stimulated GLUT4 translocation
… to require the Akt/protein kinase B substrate termed AS160 (Akt substrate of 160 kDa). In …

… Akt substrate required for the regulation of insulin-induced GLUT4 translocation by searching
the molecule sharing Akt … used to identify several new substrates of kinases (Cenni et al., …

… New signaling and cytoskeletal mechanisms of insulin-stimulated GLUT4 exocytosis are
of … engage GLUT4 exocytosis, considers cytoskeletal regulation of the stimulated GLUT4 …

… AKT is the principal insulin-regulated signal transducer for GLUT4 translocation and several
steps in the GLUT4-… Several AKT substrates, including MYOV, AS250, TBC1D4 have been …

… Recently, AS160 (Akt substrate of 160 kDa) was identified as the Akt2 target that induces …
increased insulin-induced Akt phosphorylation, GLUT4 exocytosis, and glucose incorporation. …

… proteins, including the insulin receptor substrate (IRS) proteins that provide docking sites for
… Although studies suggest that both Akt and PKCk/f act as essential downstream targets of …

… Akt substrate peptide or antibody specific to Akt inhibits insulin-stimulated GLUT4 translocation
… In L6 muscle cells, overexpression of Akt dominant-negative mutations decreases insulin-…

… In this regard, it is interesting that a bona fide insulin signal, the Akt substrate of 160 AS160/…
Although the entire process has been classically called GLUT4 translocation, we here break …

… The increase in GLUT4 exocytosis in response to insulin is powered through signalling via
the insulin receptor substrate-… The Akt axis is thought to lead to GLUT4 by phosphorylating the …

… We have previously shown that insulin-stimulated GLUT4 translocation to the PM is blocked
in 3T3-L1 adipocytes preincubated at 19 C (13). To study this translocation block … substrates. …