… glycine at this modulatory site through inhibition of glycine reuptake from the synapse via
glycine transporter-… Both preclinical and clinical evidence provide support for this approach, as …

… approaches for enhancing NMDAR function involves modification of the activity of the high
affinity glycine transporter … the early compounds being substituted glycine derivatives such as …

… size, it represents a critical evolution of the therapeutic approach. In the study, no true placebo
… In summary, glutamatergic approaches for treatment of schizophrenia were first proposed …

… of synaptic glycine could prove … glycine levels, through blockade of the glycine transporter-1
(GlyT1) potentiates NMDA receptor function in vivo and represents a rational approach …

… However, the approach remains heavily investigated as it presents potential therapeutic …
as an approach to treat the disease. However, research in the area remains quite active, as …

… as a therapeutic approach for the treatment … glycine transporter, GlyT1, are localized in close
proximity to the synaptic region. This proximity allows for close regulation of synaptic glycine…

… In the early 1990s, a glycine transporter from pig brain stem was solubilized, … of several
glycine transporter subtypes. The purified … of new therapeutic approaches for glycine-mediated …

… Interestingly, this entire regulation process is dependent on NO production since the same
antagonistic effects on glycine transport are observed with NO donor treatment and reversed …

… glycine at modulatory site on the NMDA receptors through the inhibition of glycine transporter-1
… of GlyT-1 inhibitors as a potential therapeutic approach to the treatment of schizophrenia. …

… With the development of selective and potent nontransported inhibitors … Recent in vitro studies
demonstrate that the glycine transport inhibi… An alternative approach for increasing glycine …