… One approach that has been pursued by several drug companies is to inhibit the … of glycine
transporters, in particular glycine transporter 1 (GlyT1) – the key regulator of synaptic glycine …

… The potentiation of NMDA receptor function may be a useful approach for the treatment of …
levels of glycine by blocking the glycine transporter-1 (GlyT-1) in glia cells, since glycine acts …

… and chronic pain has gained widespread recognition, with glycine receptors (GlyRs) and
glycine transporters (GlyT1 and GlyT2) now considered key therapeutic targets [1,2]. This …

… glial transporter GlyT1 catalyses the removal of glycine from the synaptic cleft, whereas GlyT2
is required for the re-uptake of glycine … the basis for future therapeutic approaches, which …

… of glycine and provide novel therapeutic targets for … Glycine transport by GlyT1 is coupled
to the co-transport of 2 Na + … However, the alternative approach of partial knock down of GlyT2 …

… 1 encephalopathy requires a multidisciplinary team approach including pediatricians,
neurologists, geneticists, genetic counselors, dietitians, physiotherapists, occupational therapists, …

… An attractive alternative approach would be to increase the glycine concentration at NMDA
synapses through the blockade of GlyT-1. The weak GlyT-1 inhibitor glycyldodecylamide was …

… with glycine transporter-1 (GlyT1), a novel target with the principle of elevating glycine levels
to … (GlyT) inhibitors is one seemingly attractive approach for new antipsychotic treatment, …

… is a therapeutic agent … glycine site is a promising approach for the pharmacotherapy of
schizophrenia. Superior to the other NMDA glycine site agents, sarcosine extends its therapeutic …

… efficacy of NMDAR antagonist therapies, the common antidepressant effects of … glycine in
individuals with risk syndrome for psychosis showed feasibility of NMDA agonist approaches …