… Therefore, a better approach is required to stimulate synaptic NMDA receptors to provide …
inhibition of the glycine transporter-1 (GlyT1), a transporter responsible for the removal of …

… Restoring the inhibitory tone therefore appears as a reasonable therapeutic approach for …
and glycine transporter selectivity of Org-25543 and ALX-1393 by measuring [ 3 H]glycine …

… direct stimulation of glycine modulatory sites, an increase in synaptic glycine levels through
the inhibition of glycine transporter 1 (GlyT1) might also be an effective approach. Indeed, …

… We hypothesized that enhancing NMDAR function by inhibiting the glycine transporter-1 (GLYT1)
would improve neuroplasticity and thereby augment benefits of non-pharmacological …

… evident that the x transporter plays an important … x transporter also plays a role in certain
CNS and eye diseases. This review focuses on the expression and function of the x transporter …

… Synaptic concentrations of glycine are regulated by two sodium-dependent glycine … maintain
low extracellular glycine concentrations by removing it from synapses via transport into glial …

… glycine transporter, GLYT1, in supporting tumour cell proliferation utilising molecular and
pharmacological approaches. … mRNA of other amino acid transporters able to transport glycine, …

… therapy is just beginning to be recognized. If successful, this would represent a novel, hitherto
unexplored, therapeutic approach … their transport function has potential for cancer therapy. …

… acid metabolism and promising therapeutic approaches. … the transport of multiple amino
acids and enable transport … one nitrogen from glycine, (2) the formylation of the glycine amino-…

The glycine transporter 1 (GlyT1) has emerged as a key novel target for the treatment of
schizophrenia. Herein, we report the synthesis and biological evaluation of aminotetralines and …