… when transporters operate in a reverse-mode. In the central nervous system, glycine may be
… In the latter, glycine transporter-1 (GlyT1) has a regulatory role for glycine concentrations. …

… Kim, KM, Kingsmore, SF, Han, H., Yang-Feng, TL, Godinot, N., Seldin, MF, Caron, MG
and Giros, B., 1994, Cloning of the human glycine transporter type 1: molecular and …

… The human glycine transporter type 2 (hGlyT2) was cloned from a spinal cord cDNA library
using … of glycine concentrations in these receptor systems implicates glycine transporters as …

… ends by active recapture through sodium- and chloride-coupled glycine transporters located
… distribution of glycine transporters is dependent on either the protein isoform or the cell type. …

… Glycine has important neurotransmitter functions at inhibitory … concentrations of glycine are
regulated by glycine transporters (… to constitute the major cell type in which the GlyT1 gene is …

… 4 Molecular cloning has revealed the existence of two major classes of glycine transporter
subtypes: type 1 (GlyT-1) and type 2 (GlyT-2). 5 These have now been further divided into …

… and GlyT2 by generating transporter-deficient mice and … transporter GlyT1 catalyses the
removal of glycine from the synaptic cleft, whereas GlyT2 is required for the re-uptake of glycine …

… However, glycine also participates in excitatory neurotransmission since it is a co‐agonist of
… glycine at synapses is mainly controlled by two sodium and chloride dependent transporters…

… and its coagonist glycine. Previous pharmacological studies suggest that the glycine
transporter type 1 (GlyT1) maintains subsaturating concentrations of glycine at synaptic NMDARs. …

… Borowsky, B.; Mezey, E.; Hoffmann, BJ Two glycine transporter variants with distinct … Cloning
of the human glycine transporter type 1: molecular and pharmacological characterization of …