Glycogen synthase kinase-3 (GSK-3) is a ubiquitously expressed serine/threonine kinase
that is particularly abundant in the CNS. Dysregulation of GSK-3 activity is believed to play a …

… Glycogen biosynthesis involves the action of several enzymes among which glycogen
synthase … We now report the first crystal structure of glycogen synthase in the presence and …

… a, or active, form, and that this is reversed by glucagon. Steiner and King'2 havemade similar
… of synthetase b to synthetase a may appear to increase the total activity, since full activity of …

… breakdown, glucose deprivation induces a decrease in GS activity that can be reversed
by re-admission of glucose. However, glycogen depletion is required for full activation of GS …

… reversed by glycogen synthase inhibition through starvation and rapamycin treatments,
suggesting a potential therapeutic value of glycogen synthase inhibition for treating glycogen … full …

… Palmityl-CoA inhibition of the enzyme is partially reversed by the glycogen synthase activator,
glucose-6-P, whereas sodium lauryl sulfate-inhibited enzyme is not reactivated by glucose-…

… therapeutic approaches to successfully halt or reverse the pathology and cognitive decline in
… In this context, glycogen synthase kinase-3β has recently been proposed as a link between …

… that emerged was to reduce glycogen synthase-1 (GYS1) activity, thereby interfering with
chain elongation during glycogen synthesis, in order to prevent glycogen accumulation and LB …

… We examined the signaling pathways regulating glycogen synthase (GS) in primary cultures
of rat hepatocytes. The activation of GS by insulin and glucose was completely reversed by …

… it brought about full activation of a … full activity upon the addition of sdt. This last step,
presumably nonenzymatic, seems to be an unmasking of active sites by the salts; it can be reversed …