… Glycogen synthase kinase 3β (GSK3β), a multifunctional serine/threonine kinase found in
… of insulin-dependent glycogen synthesis. It is now known that GSK3β functions in diverse …

… ) and this in turn inhibits the GSK-3β activity via phosphorylation of ser9, allowing glycogen
synthase to be dephosphorylated and glycogen synthesis to be started [28]. Inactivation of …

… GSK-3 is the regulation of the activity of glycogen synthase (GS), an enzyme that mediates
the conversion of glucose to glycogen. … inactive form due to phosphorylation by GSK-3. Under …

… Glycogen synthase kinase-3β (GSK3β) is a fascinating enzyme with an astoundingly diverse
number of actions in intracellular signaling systems. GSK3β … GSK3β phosphorylates and …

… For some substrates, like glycogen synthase, phosphorylation by GSK-3 requires prior
phosphorylation of a serine residue C-terminal to the target site. The specificity of this priming site …

… The serine/threonine kinase glycogen synthase kinase-3 (GSK-3) was initially identified as
a key regulator of insulin-dependent glycogen synthesis. GSK-3 was subsequently shown to …

… GSK-3 inhibition has been shown to enhance insulin sensitivity and promote glycogen
synthesis, suggesting that GSK-3 is a … Recent data shows that GSK-3α and GSK-3β have distinct …

… glycogen synthase (GS) in fractioned extracts of rabbit skeletal muscle [1-2]. GSK-3 is a …
isoform selectivity, as they all show similar potencies towards purified GSK-3α and GSK3β. …

… For example, inhibition of GSK-3 is important for the activation of glycogen synthase. In …
of GSK-3, work in concert to activate glycogen synthase and promote glycogen synthesis. …

… Three closely related forms of glycogen synthase kinase 3 (GSK-3α, GSK-3β and GSK-3β2)
have a major role in Wnt and Hedgehog signaling pathways and regulate the cell-division …