Glycogen synthase kinase 3β (GSK3β) in tumorigenesis and cancer chemotherapy
J Luo - Cancer letters, 2009 - Elsevier
… Glycogen synthase kinase 3β (GSK3β), a multifunctional serine/threonine kinase found in
… of insulin-dependent glycogen synthesis. It is now known that GSK3β functions in diverse …
… of insulin-dependent glycogen synthesis. It is now known that GSK3β functions in diverse …
Glycogen synthase kinase-3 beta (GSK-3β) signaling: implications for Parkinson's disease
… ) and this in turn inhibits the GSK-3β activity via phosphorylation of ser9, allowing glycogen
synthase to be dephosphorylated and glycogen synthesis to be started [28]. Inactivation of …
synthase to be dephosphorylated and glycogen synthesis to be started [28]. Inactivation of …
[HTML][HTML] Glycogen synthase kinase-3 (GSK-3)-targeted therapy and imaging
MK Pandey, TR DeGrado - Theranostics, 2016 - ncbi.nlm.nih.gov
… GSK-3 is the regulation of the activity of glycogen synthase (GS), an enzyme that mediates
the conversion of glucose to glycogen. … inactive form due to phosphorylation by GSK-3. Under …
the conversion of glucose to glycogen. … inactive form due to phosphorylation by GSK-3. Under …
The multifaceted roles of glycogen synthase kinase 3β in cellular signaling
CA Grimes, RS Jope - Progress in neurobiology, 2001 - Elsevier
… Glycogen synthase kinase-3β (GSK3β) is a fascinating enzyme with an astoundingly diverse
number of actions in intracellular signaling systems. GSK3β … GSK3β phosphorylates and …
number of actions in intracellular signaling systems. GSK3β … GSK3β phosphorylates and …
Glycogen synthase kinase-3: properties, functions, and regulation
A Ali, KP Hoeflich, JR Woodgett - Chemical reviews, 2001 - ACS Publications
… For some substrates, like glycogen synthase, phosphorylation by GSK-3 requires prior
phosphorylation of a serine residue C-terminal to the target site. The specificity of this priming site …
phosphorylation of a serine residue C-terminal to the target site. The specificity of this priming site …
Glycogen synthase kinase 3: a key regulator of cellular fate
JE Forde, TC Dale - Cellular and molecular life sciences, 2007 - Springer
… The serine/threonine kinase glycogen synthase kinase-3 (GSK-3) was initially identified as
a key regulator of insulin-dependent glycogen synthesis. GSK-3 was subsequently shown to …
a key regulator of insulin-dependent glycogen synthesis. GSK-3 was subsequently shown to …
Targeting glycogen synthase kinase-3 (GSK-3) in the treatment of Type 2 diabetes
K MacAulay, JR Woodgett - Expert opinion on therapeutic targets, 2008 - Taylor & Francis
… GSK-3 inhibition has been shown to enhance insulin sensitivity and promote glycogen
synthesis, suggesting that GSK-3 is a … Recent data shows that GSK-3α and GSK-3β have distinct …
synthesis, suggesting that GSK-3 is a … Recent data shows that GSK-3α and GSK-3β have distinct …
Glycogen synthase kinase-3 (GSK-3) inhibitors for the treatment of Alzheimer's disease
M Medina, J Avila - Current pharmaceutical design, 2010 - ingentaconnect.com
… glycogen synthase (GS) in fractioned extracts of rabbit skeletal muscle [1-2]. GSK-3 is a …
isoform selectivity, as they all show similar potencies towards purified GSK-3α and GSK3β. …
isoform selectivity, as they all show similar potencies towards purified GSK-3α and GSK3β. …
Glycogen synthase kinase 3: an emerging therapeutic target
H Eldar-Finkelman - Trends in molecular medicine, 2002 - cell.com
… For example, inhibition of GSK-3 is important for the activation of glycogen synthase. In …
of GSK-3, work in concert to activate glycogen synthase and promote glycogen synthesis. …
of GSK-3, work in concert to activate glycogen synthase and promote glycogen synthesis. …
Pharmacological inhibitors of glycogen synthase kinase 3
L Meijer, M Flajolet, P Greengard - Trends in pharmacological sciences, 2004 - cell.com
… Three closely related forms of glycogen synthase kinase 3 (GSK-3α, GSK-3β and GSK-3β2)
have a major role in Wnt and Hedgehog signaling pathways and regulate the cell-division …
have a major role in Wnt and Hedgehog signaling pathways and regulate the cell-division …
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