… GSK-3 was originally identified as one of five protein kinases that phosphorylate the rate-limiting
enzyme of glycogen synthesis, glycogen synthase (GS). Following peptide sequencing …

Glycogen synthase kinase-3β (GSK3β) is a fascinating enzyme with an astoundingly diverse
number of actions in intracellular signaling systems. GSK3β activity is regulated by serine (…

… Glycogen synthase kinase-3 (GSK3) may be the busiest kinase in most cells, with over 100
known substrates to deal with. How does GSK3 maintain control to selectively phosphorylate …

… This review concentrates on a single protein-serinc kinase, glycogen synthase kinase-3 (OSKo3)~
that has unexpectedly surfaced in several disparate areas of biolo~ and, as a g~…

… isoform of tau protein kinase I/glycogen synthase kinase 3β. … Glycogen synthase kinase-3β
is highly activated in nuclei … 3-kinase/Akt/glycogen synthase kinase 3β signaling pathway. …

… of glycogen synthase kinase 3 (GSK-3), a serine/threonine protein kinase that phosphorylates
glycogen synthase. … The multifaceted roles of glycogen synthase kinase 3β in cellular …

Glycogen synthase kinase-3 (GSK-3)-α and -β are closely related protein-serine kinases,
which act as inhibitory components of Wnt signalling during embryonic development and cell …

… -3β lies between subdomains X and XI; GSK-3β is the only … of casein kinase II and glycogen
synthase kinase 3. J. Biol. … basis for recruitment of glycogen synthase kinase 3beta to the axin…

… Three closely related forms of glycogen synthase kinase 3 (GSK-3α, GSK-3β and GSK-3β2)
have a major role in Wnt and Hedgehog signaling pathways and regulate the cell-division …

… targets for the treatment of this condition including glycogen synthase kinase-3β (GSK3-β).
GSK3-β is considered a key player in AD pathophysiology since dysregulation of this …