Probable activation of the opioid receptor-nitric oxide-cyclic GMP-K+ channels pathway by codeine

MI Ortiz, J Castro-Olguín, N Peña-Samaniego… - Pharmacology …, 2005 - Elsevier
… possible participation of this pathway in the antinociceptive … (TEA) and the opioid receptor
blocker naloxone prevented … the opioid receptor-NO-cyclic GMP-K + channels pathway in …

Antinociceptive effect of tadalafil in various pain models: Involvement of opioid receptors and nitric oxide cyclic GMP pathway

MM Mehanna, S Domiati, HN Chmaisse… - Toxicology and applied …, 2018 - Elsevier
… Moreover, several studies have proved that peripheral opioid receptor activation inhibits
anti-inflammatory pain and activates l-arginine/NO/cGMP pathway (Cunha et al., 2012; Ortiz et al…

The κ-opioid agonist (±)-bremazocine elicits peripheral antinociception by activation of the L-arginine/nitric oxide/cyclic GMP pathway

LH Amarante, IDG Duarte - European Journal of Pharmacology, 2002 - Elsevier
… In view of the scarce information about the analgesic mechanism of κ-opioid receptor … , a
κ-opioid receptor agonist. Three drugs all interfering with the l-arginine/NO/cyclic GMP pathway

[HTML][HTML] Opioid receptor and NO/cGMP pathway as a mechanism of peripheral antinociceptive action of the cannabinoid receptor agonist anandamide

GML Reis, D Pacheco, AC Perez, A Klein, MA Ramos… - Life sciences, 2009 - Elsevier
… whether the opioid system and the nitric oxide pathway were … pathway. For this purpose,
the hyperalgesia rat paw model … opioid receptor and with NO/cyclic GMP pathway were tested. …

δ-Opioid receptor agonist SNC80 elicits peripheral antinociception via δ1 and δ2 receptors and activation of the l-arginine/nitric oxide/cyclic GMP pathway

DF Pacheco, GML Reis, JN Francischi, MSA Castro… - Life sciences, 2005 - Elsevier
… the role of δ 1 and δ 2 opioids receptors, as well the involvement of the l-arginine/NO/cGMP
pathway in the peripheral antinociception induced by δ-opioid receptor agonist (+)-4-[(αR)-α-…

The peripheral L-arginine–nitric oxide–cyclic GMP pathway and ATP-sensitive K+ channels are involved in the antinociceptive effect of crotalphine on neuropathic …

VP Gutierrez, VO Zambelli, G Picolo… - Behavioural …, 2012 - journals.lww.com
opioid receptors; the present work was carried out to characterize the type of opioid receptor
… of the peripheral L-arginine/NO/cGMP pathway and opening of K + channels. In this study, …

The molecular basis of opioid receptor function

WF Simonds - Endocrine Reviews, 1988 - academic.oup.com
… GTP and its nonhydrolyzable analogs including guanyl-5'-yl imidodiphosphate (Gpp[NH]p)
and guanosine 5'-(7-thio)-triphosphate (GTP[S]), and GDP but not GMP inhibited opioid ago…

[PDF][PDF] Opioid receptors and their relevance to anaesthesia

BJ Pleuvry - BJA: British Journal of Anaesthesia, 1993 - Citeseer
… There is also some suggestion that a nitric oxide-cyclic GMP signalling pathway is involved
in peripheral analgesia [18], but whether or not this is important for the peripheral activity of …

Molecular mechanisms of opioid receptor-dependent signaling and behavior

R Al-Hasani, MR Bruchas - The Journal of the American Society of …, 2011 - pubs.asahq.org
… studies with opioid behavioral pharmacology. We discuss the advances in opioid receptor
… the connections between signaling at opioid receptors, tolerance to opioids, and behavioral …

Modulation of opioid actions by nitric oxide signaling

N Toda, S Kishioka, Y Hatano, H Toda… - The Journal of the …, 2009 - pubs.asahq.org
… Morphine and other opioid agonists exert analgesia through μ-opioid receptors at spinal
and … the opioid receptor- nitric oxide-cyclic GMP-K + channels pathway to produce its effect. …