Role of oxidative stress in the apoptotic cell death of cultured cerebellar granule neurons

A Valencia, J Morán - Journal of neuroscience research, 2001 - Wiley Online Library
… in neuronal apoptotic cell death using CGN apoptotic death as a model of study. When CGN
grown in a medium containing 25 mM KCl are transferred to a 5 mM KCl medium, cells die …

Depolarization or glutamate receptor activation blocks apoptotic cell death of cultured cerebellar granule neurons

GM Yan, B Ni, M Weller, KA Wood, SM Paul - Brain research, 1994 - Elsevier
granule neurons cultured in low K ÷ medium. In contrast, cell death induced by exposing
cerebellar granule neurons to … Thus, at least two distinct types of delayed cell death can be …

Activation of caspase-3 in single neurons and autophagic granules of granulovacuolar degeneration in Alzheimer's disease: evidence for apoptotic cell death

C Stadelmann, TL Deckwerth, A Srinivasan… - The American journal of …, 1999 - Elsevier
… presenilin 2 to the control of cell death.1, 2, 3, 4 Exposure of neuronal cultures to βA4, the …
neuronal cell death has been observed in primary cultures of Down's syndrome (DS. neurons, …

Neurotrophins protect cultured cerebellar granule neurons against the early phase of cell death by a twocomponent mechanism

MJ Courtney, KEO Åkerman… - Journal of Neuroscience, 1997 - Soc Neuroscience
… a mature neuronal phenotype, … that cells cultured with serum undergo two phases of cell
death. By 6 din vitro, 30–50% of the cells present are dead; after this time the remaining cells die…

CDP-choline prevents glutamate-mediated cell death in cerebellar granule neurons

C Mir, J Clotet, R Aledo, N Durany, J Argemí… - Journal of Molecular …, 2003 - Springer
… in PC12 cells and in primary cultures of fetal neurons, and is … mediated neuronal cell death
in cerebellar granule cells and to … neuronal cell death induced by glutamate, reducing almost …

Mitofusin 2 protects cerebellar granule neurons against injury-induced cell death

A Jahani-Asl, ECC Cheung, M Neuspiel… - Journal of Biological …, 2007 - ASBMB
… against Acute Injury—To examine whether activating mitochondrial fusion could protect
neurons against cell death, we created adenovirus vectors containing the CFP-tagged wild-type …

Apoptosis and autophagy in rat cerebellar granule neuron death: Role of reactive oxygen species

P Maycotte, A Guemez‐Gamboa… - Journal of neuroscience …, 2010 - Wiley Online Library
cell death in rat cerebellar granule neuron (CGN) culture, a widespread model for the study
of neuronal death… Potassium deprivation (K5) and staurosporine (STS) were used for death

Polyamines prevent apoptotic cell death in cultured cerebellar granule neurons

J Harada, M Sugimoto - Brain research, 1997 - Elsevier
… of cerebellar granule neurons in medium … death of cultured cerebellar granule neurons.
Our results indicate that polyamines prevent apoptotic cell death of postmitotic brain neurons

Pituitary adenylate cyclase-activating polypeptide protects rat cerebellar granule neurons against ethanol-induced apoptotic cell death

D Vaudry, C Rousselle, M Basille… - Proceedings of the …, 2002 - National Acad Sciences
… Incubation of granule cells with PACAP prevented ethanol-… Cotreatment of granule cells
with PACAP provoked a … agent against ethanol-induced neuronal cell death. The fact that …

Reactive oxygen species induce different cell death mechanisms in cultured neurons

A Valencia, J Morán - Free Radical Biology and Medicine, 2004 - Elsevier
… In agreement with these studies, in the present work we found that O 2 radical dot − , 1 O
2 , and H 2 O 2 induce cell death in cultures of cerebellar granule neurons. Also, we further …