… cerebellar granule neurons can be rescued beyond the initiation of DNA fragmentation by …
to death as the latest time point at which neurons can be rescued after switch to low K + (5 mM…

… ] and an increase in the percentage of neurons showing signs of DNA fragmentation (insitu
terminal … DNA fragmentation and oxidative stress, that preceded this type of neuronal death. …

… In general, labeled neurons revealed a loose and finely granular chromatin structure and
did not show the above mentioned clear morphological criteria of apoptosis, ie chromatin …

… neuronal death remains to be resolved. To address this question, we examined the
consequences of K deprivation in granule neuron … for death of granule neurons induced by K de…

… , DNA fragmentation into nucleosomal-size fragments, activation of specific enzymes and
proteases, etc. (Martin and Green, 1995; Cohen, 1997; Nardi et al., 1997; Ni et al., 1997; Morán …

… , few scattered groups of apoptotic granule neurons were observed in the homolateral … in
the granule layer of the deafferentated area. The time window of DNA fragmentation in granule …

… detect substantial differences in DNA fragmentation, we also … regarding the per cent DNA
fragmentation in the cerebellum … conditions (per cent DNA fragmentation, 24 h after a single …

… of cerebellar granule cells without intemucleosomal DNA fragmentation. DNA fragmentation
… Thus, at least in primary cerebellar granule cell cultures, the chromatin condensation and …

… (G) DNA fragmentation of cultured granule cells incubated for 12 h in the absence (Ctrl) or
presence of H 2 O 2 (12 µm), or H 2 O 2 (12 µm) plus PACAP (10 −7 m). DNA laddering was …

… granule neurons, we hypothesize that the functional innervation of postmigratory granule
neurons … Methods for assessing granule neuron viability and DNA fragmentation are described …