TRPC channels promote cerebellar granule neuron survival

Y Jia, J Zhou, Y Tai, Y Wang - Nature neuroscience, 2007 - nature.com
… In the present study, we have examined the role of TRPC channels in neuronal survival
in both CGN cultures and neonatal cerebellum. We found that TRPC3 and 6 are required for …

Characterization of TrkB receptor‐mediated signaling pathways in rat cerebellar granule neurons: involvement of protein kinase C in neuronal survival

U Zirrgiebel, Y Ohga, B Carter… - Journal of …, 1995 - Wiley Online Library
… increased the survival of cultured cerebellar granule neu… survival of granular neurons, we
show here activation of PKC after BDNF or TPA treatment and blocking of the observed survival

[HTML][HTML] Neuronal survival in the brain: neuron type-specific mechanisms

U Pfisterer, K Khodosevich - Cell death & disease, 2017 - nature.com
… Ablation or enhancement of olfactory activity onto maturing granule cells decreases or
increases their survival, respectively. However, similar enhancement does not affect …

NF‐κB is involved in the survival of cerebellar granule neurons: association of Iκβ phosphorylation with cell survival

E Koulich, T Nguyen, K Johnson… - Journal of …, 2001 - Wiley Online Library
… Using this paradigm, we show that NF-κB is necessary for neuronal survival and that
overexpression of certain NF-κB members can prevent low K + (LK)-induced apoptosis. Interestingly…

[HTML][HTML] The transcription factor NFAT3 mediates neuronal survival

AB Benedito, M Lehtinen, R Massol, UG Lopes… - Journal of Biological …, 2005 - ASBMB
… these signals promote neuronal survival are … survival of granule neurons of the developing
cerebellum. NFAT3 accumulated in the nucleus of primary granule neurons under survival

[HTML][HTML] An essential role for Rac/Cdc42 GTPases in cerebellar granule neuron survival

DA Linseman, T Laessig, MK Meintzer… - Journal of Biological …, 2001 - ASBMB
neuronal survival using primary cerebellar granule neurons. Clostridium difficile toxin B, a
specific inhibitor of Rho, Rac, and Cdc42, induced apoptosis of granule neuronssurvival

Brain‐derived neurotrophic factor is a survival factor for cultured rat cerebellar granule neurons and protects them against glutamate‐induced neurotoxicity

D Lindholm, G Dechant, CP Heisenberg… - European Journal of …, 1993 - Wiley Online Library
… of different neurotrophins on the survival and proliferation of rat cerebellar granule cells
in culture. These neurons express trkB and trkC, the putative neuronal receptors for brainderived …

Cultures of cerebellar granule neurons

PM Bilimoria, A Bonni - Cold Spring Harbor Protocols, 2008 - cshprotocols.cshlp.org
… Cerebellar granule neurons have proven invaluable in uncovering the signaling pathways
governing neuronal survival, migration, and differentiation. Studies of neuronal apoptosis …

Induction of apoptosis in cerebellar granule neurons by low potassium: inhibition of death by insulin-like growth factor I and cAMP.

SR D'Mello, C Galli, T Ciotti… - Proceedings of the …, 1993 - National Acad Sciences
survival of mature cerebellar granule neurons is … survival effect on our neuronal cultures
maintained in low K+ (unpublished observation). It is possible that cerebellar granule neurons

Depolarization or glutamate receptor activation blocks apoptotic cell death of cultured cerebellar granule neurons

GM Yan, B Ni, M Weller, KA Wood, SM Paul - Brain research, 1994 - Elsevier
granule neuron survival by blocking their programmed death via apoptosis. Cerebellar granule
neurons … Cerebellar granule neurons are among the most abundant neuronal phenotype …