Protection against MPP+ neurotoxicity in cerebellar granule cells by antioxidants

RA González-Polo, G Soler, A Rodrıguezmartın… - Cell biology …, 2004 - Elsevier
… cerebellar granule cells (CGCs) with 50μM MPP + . Co-treatment with antioxidants such as
… We also tested the protective effects of an iron chelator (deferoxamine mesylate, DFx) and a …

… of serum from primary cultures of cerebellar granule neurons induces oxidative stress and DNA fragmentation: protection with antioxidants and glutamate receptor …

C Atabay, CM Cagnoli, E Kharlamov… - Journal of …, 1996 - Wiley Online Library
… First, we observed a significant protective effect of a number of antioxidants. Secondly, by …
In our experimental conditions, neuroprotection was achieved with the glutamate receptor an…

Inhibition of free radical production or free radical scavenging protects from the excitotoxic cell death mediated by glutamate in cultures of cerebellar granule neurons

E Ciani, L Grøneng, M Voltattorni, V Rolseth… - Brain research, 1996 - Elsevier
… In this model system, we have tested the protective effects of … ) as well as of various antioxidants
and free radical scavengers. … the levels of protection given by antioxidant strategies with …

Natural antioxidants protect neurons in Alzheimer's disease and Parkinson's disease

B Zhao - Neurochemical Research, 2009 - Springer
… by Fenton reaction induced apoptosis in cerebellar granule cells, which was associated with
… a mixture of flavonoids and terpens protected cerebellar granule cell from oxidative damage …

Role of oxidative stress in the apoptotic cell death of cultured cerebellar granule neurons

A Valencia, J Morán - Journal of neuroscience research, 2001 - Wiley Online Library
… On the other hand, the protective effect of antioxidants observed in this study was not
mediated by a modification of cytosolic Ca 2+ levels. Thus, although Ca 2+ levels seem to be the …

Curcumin pretreatment induces Nrf2 and an antioxidant response and prevents hemin‐induced toxicity in primary cultures of cerebellar granule neurons of rats

S González-Reyes, S Guzmán-Beltrán… - Oxidative medicine …, 2013 - Wiley Online Library
… These data strongly suggest that HO-1 and GSH play a major role in the protective effect of
antioxidant response that may play an important role in the protective effect of this antioxidant

Cr (VI) induced oxidative stress and toxicity in cultured cerebellar granule neurons at different stages of development and protective effect of R osmarinic acid

A Dashti, M Soodi, N Amani - Environmental toxicology, 2016 - Wiley Online Library
… Interestingly, Rosmarinic acid, as a natural antioxidant, could protect mature but not
immature neurons against Cr (VI) induced toxicity. Our findings revealed vulnerability of mature …

Nutritional antioxidants as antidegenerative agents

C De Ruvo, R Amodio, S Algeri, N Martelli… - International Journal of …, 2000 - Elsevier
… In this study, primary cultures of cerebellar granule neurons were … natural antioxidants did
not have any protective effect on … a limited number of natural antioxidants are provided with …

Protective effect of antioxidants on neuronal dysfunction and plasticity in Huntington's disease

T Velusamy, AS Panneerselvam… - Oxidative medicine …, 2017 - Wiley Online Library
neurons can be protected against METH-induced neurotoxicity and striatal dopamine depletion
by use of selective antioxidants, … (GCL) and differentiate into new granule neurons of the …

Inhibition of excessive neuronal apoptosis by the calcium antagonist amlodipine and antioxidants in cerebellar granule cells

RP Mason, PR Leeds, RF Jacob… - Journal of …, 1999 - Wiley Online Library
… 9), with maximal protection achieved when the antioxidants were added between 6 and
10 DIV (less protection was observed when the antioxidants were added at 13 DIV). …